ethyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-galactopyranoside | 10353-13-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ethyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-galactopyranoside
• 英文别名: Ethyl-2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-galactopyranosid；ethyl-(tri-O-acetyl-2-acetylamino-2-deoxy-β-D-galactopyranoside)；Aethyl-(tri-O-acetyl-2-acetylamino-2-desoxy-β-D-galactopyranosid)；[(2R,3R,4R,5R,6R)-5-acetamido-3,4-diacetyloxy-6-ethoxyoxan-2-yl]methyl acetate
• CAS: 10353-13-6
• 化学式: C₁₆H₂₅NO₉
• 分子量: 375.376
• InChiKey: POOQFLLMEIHRRF-IBEHDNSVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  127
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  ethyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-galactopyranoside 在 甲醇 、 barium methoxide 作用下， 生成 Ethyl-β-D-N-acetylgalactosamin
  参考文献：
  名称：

  Acetohalogeno Derivatives and Glycosides of D-Galactosamine¹

  摘要：

  DOI：

  10.1021/ja01556a040
• 作为产物：
  描述：

  3,4,6-tri-O-acetyl-2-deoxy-2-nitroso-α-D-galactopyranosyl chloride 在 platinum(IV) oxide 氢气 、 sodium carbonate 作用下， 以 1,4-二氧六环 、 甲醇 、 水 为溶剂， 反应 16.0h， 生成 ethyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-galactopyranoside
  参考文献：
  名称：

  Nagabhushan, T. L., Canadian Journal of Chemistry, 1980, vol. 58, p. 2720 - 2723

  摘要：

  DOI：

文献信息

• BLOCK COPOLYMERS
  申请人：GENEVANT SCIENCES GMBH

  公开号：US20210023235A1

  公开（公告）日：2021-01-28

  Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.
• MULTIVALENT LIGAND CLUSTERS FOR TARGETED DELIVERY OF THERAPEUTIC AGENTS
  申请人：Mitotherapeutix LLC

  公开号：US20220175934A1

  公开（公告）日：2022-06-09

  Targeting ligand clusters, and methods of preparing same, are described. A targeting ligand cluster may include first linkers attached to phenolic hydroxyl groups of gallic acid, and one or more targeting ligands attached to each of the first linkers. The targeting ligand cluster may also include a second linker attached to a carboxylic acid of the gallic acid, and at least one of a protecting group, a phosphoramidite, or an oligonucleotide attached to the second linker.