4'-methyl-4-aminochalcone | 30278-84-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 4'-methyl-4-aminochalcone
• 英文别名: 4'-Methyl-4-aminochalkon；3-(4-aminophenyl)-1-(4-methylphenyl)prop-2-en-1-one
• CAS: 30278-84-3
• 化学式: C₁₆H₁₅NO
• 分子量: 237.301
• InChiKey: UUDOELBGKMGBFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.47
• 重原子数：
  18.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  43.09
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  4'-methyl-4-aminochalcone 、 对甲苯异氰酸酯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以84%的产率得到4-(4"-methylphenylurenyl)-4'-methylchalcone
  参考文献：
  名称：

  Evaluation of new chalcone derivatives as polyphenol oxidase inhibitors

  摘要：

  A newly series of 4-(phenylurenyl) chalcone (4a-j) and 4'-(phenylurenyl/thiourenyl)chalcone (9a-l) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase has been purified from banana on an affinity gel comprised of Sepharose 4B-L-tyrosine-p-aminobenzoic acid. The result showed that 4a-j inhibited the PPO enzyme activity. Conversely, 9a-h and 9i-l showed activator effect on tyrosinase enzyme activity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.09.130
• 作为产物：
  描述：

  1-(4-甲基苯基)-3-(4-硝基苯基)丙-2-烯-1-酮 在 tin(II) chloride dihdyrate 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以84%的产率得到4'-methyl-4-aminochalcone
  参考文献：
  名称：

  Evaluation of new chalcone derivatives as polyphenol oxidase inhibitors

  摘要：

  A newly series of 4-(phenylurenyl) chalcone (4a-j) and 4'-(phenylurenyl/thiourenyl)chalcone (9a-l) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase has been purified from banana on an affinity gel comprised of Sepharose 4B-L-tyrosine-p-aminobenzoic acid. The result showed that 4a-j inhibited the PPO enzyme activity. Conversely, 9a-h and 9i-l showed activator effect on tyrosinase enzyme activity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.09.130