8-Oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-6-carboxylic acid methyl ester | 301823-57-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-Oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-6-carboxylic acid methyl ester
• 英文别名: methyl 8-oxo-5H-[1,3]dioxolo[4,5-g]quinoline-6-carboxylate
• CAS: 301823-57-4
• 化学式: C₁₂H₉NO₅
• 分子量: 247.207
• InChiKey: NFSIKOAYLZLQGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  73.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  8-Oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-6-carboxylic acid methyl ester 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 N-carbamimidoyl-8-ethoxy-[1,3]dioxolo[4,5-g]quinoline-6-carboxamide
  参考文献：
  名称：

  Synthesis and evaluation of quinoline carboxyguanidines as antidiabetic agents

  摘要：

  The synthesis and in vivo activities of a series of substituted quinoline carboxyguanidines as a possible novel class of antidiabetic agents is described. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00354-1
• 作为产物：
  描述：

  3,4-亚甲二氧基苯胺 以 甲醇 、 二苯醚 为溶剂， 生成 8-Oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-6-carboxylic acid methyl ester
  参考文献：
  名称：

  Synthesis and evaluation of quinoline carboxyguanidines as antidiabetic agents

  摘要：

  The synthesis and in vivo activities of a series of substituted quinoline carboxyguanidines as a possible novel class of antidiabetic agents is described. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00354-1

文献信息

• Synthesis and evaluation of quinoline carboxyguanidines as antidiabetic agents
  作者：Dolorès Edmont、Richard Rocher、Christophe Plisson、Jacques Chenault

  DOI：10.1016/s0960-894x(00)00354-1

  日期：2000.8

  The synthesis and in vivo activities of a series of substituted quinoline carboxyguanidines as a possible novel class of antidiabetic agents is described. (C) 2000 Elsevier Science Ltd. All rights reserved.