1-Phenyl-7,8-dihydro-6H-[1,4]diazepino[6,7,1-ij]quinoline-3,4-dione 3-oxime | 126149-69-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 1-Phenyl-7,8-dihydro-6H-[1,4]diazepino[6,7,1-ij]quinoline-3,4-dione 3-oxime
• CAS: 126149-69-7
• 化学式: C₁₈H₁₅N₃O₂
• 分子量: 305.336
• InChiKey: OLEZJUOCQKLKQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  23.0
• 可旋转键数：
  1.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  67.48
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  1-Phenyl-7,8-dihydro-6H-[1,4]diazepino[6,7,1-ij]quinoline-3,4-dione 3-oxime 在 Ru-carbon O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 氢气 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 N-(13-oxo-10-phenyl-1,11-diazatricyclo[7.4.1.05,14]tetradeca-5(14),6,8,10-tetraen-12-yl)-1H-indole-2-carboxamide
  参考文献：
  名称：

  Synthesis and structure–activity relationships of 4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1- hi ]indoles: novel PDE4 inhibitors

  摘要：

  A novel series of benzodiazepine derivatives have been discovered as inhibitors of PDE4 enzymes. We have found that our compounds are selective versus other PDE enzymes, and that the activity can be modulated by specific structural modifications. One compound exhibited a strong eosinophilic infiltration inhibiting action on sensitized Brown-Norway rats (compound 9, 5.1 mg/kg p.o.), moreover this compound is not emetic at 3 mg/kg i.v. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00573-9
• 作为产物：
  描述：

  1-phenyl-7,8-dihydro-3H,6H-[1,4]diazepino[6,7,1-ij]quinolin-4-one 在 potassium tert-butylate 、 亚硝酸异戊酯 作用下， 以 四氢呋喃 为溶剂， 生成 1-Phenyl-7,8-dihydro-6H-[1,4]diazepino[6,7,1-ij]quinoline-3,4-dione 3-oxime
  参考文献：
  名称：

  Synthesis and structure–activity relationships of 4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1- hi ]indoles: novel PDE4 inhibitors

  摘要：

  A novel series of benzodiazepine derivatives have been discovered as inhibitors of PDE4 enzymes. We have found that our compounds are selective versus other PDE enzymes, and that the activity can be modulated by specific structural modifications. One compound exhibited a strong eosinophilic infiltration inhibiting action on sensitized Brown-Norway rats (compound 9, 5.1 mg/kg p.o.), moreover this compound is not emetic at 3 mg/kg i.v. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00573-9