N-(4-(4-bromophenyl)thiazol-2-yl)-1-phenylmethanimine | 468079-14-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(4-(4-bromophenyl)thiazol-2-yl)-1-phenylmethanimine
• CAS: 468079-14-3
• 化学式: C₁₆H₁₁BrN₂S
• 分子量: 343.247
• InChiKey: XQCLNBYKCUBERW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.32
• 重原子数：
  20.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.25
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  N-(4-(4-bromophenyl)thiazol-2-yl)-1-phenylmethanimine 、 2-氨基-5-硝基苯甲酸 在 铜 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以47%的产率得到2-((4-[2-((1E)-1-aza-2-(phenyl)vinyl)-1,3-thiazol-4-yl]-phenyl)amino)-5-nitrobenzoic acid
  参考文献：
  名称：

  Synthesis, Characterization, and Biological Activity of Some New Benzoic Acid and Thiazoloacridine Derivatives

  摘要：

  A series of acridine derivatives 5have been synthesized by cylization of benzoic acid derivatives 4using POCl3. Compounds 4 were synthesized by Ullamnn Condensation of bromo derivatives 2 and substituted anthranilic acid, respectively, which in turn have been prepared from the Schiff bases of 4-aryl-2-amino thiazole 1 and substituted aldehydes. Biological activities of all the compounds have been studied using gram positive and gram negative bacteria and their anti-fungal activity using fungal species Aspergillus Parasiticus and Sclerotium Rolfsii. All structures of the newly synthesized heterocyclic compounds were established based on elemental analyses, IR, H-1 NMR, C-13 NMR, and mass spectra.

  DOI：

  10.1080/10426500701852687
• 作为产物：
  描述：

  2-氨基-4-(4-溴苯基)噻唑 、 苯甲醛 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成 N-(4-(4-bromophenyl)thiazol-2-yl)-1-phenylmethanimine
  参考文献：
  名称：

  Synthesis, Characterization, and Biological Activity of Some New Benzoic Acid and Thiazoloacridine Derivatives

  摘要：

  A series of acridine derivatives 5have been synthesized by cylization of benzoic acid derivatives 4using POCl3. Compounds 4 were synthesized by Ullamnn Condensation of bromo derivatives 2 and substituted anthranilic acid, respectively, which in turn have been prepared from the Schiff bases of 4-aryl-2-amino thiazole 1 and substituted aldehydes. Biological activities of all the compounds have been studied using gram positive and gram negative bacteria and their anti-fungal activity using fungal species Aspergillus Parasiticus and Sclerotium Rolfsii. All structures of the newly synthesized heterocyclic compounds were established based on elemental analyses, IR, H-1 NMR, C-13 NMR, and mass spectra.

  DOI：

  10.1080/10426500701852687