4(5)-(环己烯-4-基甲基)咪唑 | 317339-19-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 4(5)-(环己烯-4-基甲基)咪唑
• 英文名称: 4(5)-(cyclohexene-4-ylmethyl) imidazole
• 英文别名: 4-Cyclohex-3-enylmethyl-1H-imidazole；5-(cyclohex-3-en-1-ylmethyl)-1H-imidazole
• CAS: 317339-19-8
• 化学式: C₁₀H₁₄N₂
• mdl: MFCD09908402
• 分子量: 162.235
• InChiKey: WXCDRTJXHWUZBK-UHFFFAOYSA-N

物化性质

• 沸点：
  342.3±11.0 °C(Predicted)
• 密度：
  1.084±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-(cyclohex-3-en-1-yl)acetonitrile 、 (三甲基硅基)甲基化异腈 在 potassium tert-butylate 、 potassium fluoride 作用下， 以 乙二醇二甲醚 为溶剂， 反应 8.75h， 以52%的产率得到4(5)-(环己烯-4-基甲基)咪唑
  参考文献：
  名称：

  Process for the synthesis of imidazoles

  摘要：

  本发明提供了一种通过将氰基化合物与硅烷基异氰化合物反应制备咪唑的方法。这些咪唑是有用的药理活性化合物和/或用于制备药理活性化合物的中间体。

  公开号：

  US20050101785A1

文献信息

• IMIDIAZOLE DERIVATIVES AND THEIR USE AS AGONISTS SELECTIVE AT ALPHA 2B OR 2B/2C ADRENERGIC RECEPTORS
  申请人：ALLERGAN, INC.

  公开号：EP1370533B1

  公开（公告）日：2015-05-06
• PROCESS FOR THE SYNTHESIS OF IMIDAZOLES
  申请人：Dolby J. Lloyd

  公开号：US20070185332A1

  公开（公告）日：2007-08-09

  The present invention provides a process for the preparation of imidazoles by reacting a cyano compound with a silylalkylisocyanide compound. Such imidazoles are useful pharmacologically-active compounds and/or intermediates for the preparation of pharmacologically-active compounds.
• Process for the Synthesis of Imidazoles
  申请人：Dolby J. Lloyd

  公开号：US20070249843A1

  公开（公告）日：2007-10-25

  The present invention provides a process for the preparation of imidazoles by reacting a cyano compound with a silylalkylisocyanide compound. Such imidazoles are useful pharmacologically-active compounds and/or intermediates for the preparation of pharmacologically-active compounds.
• ALPHA-2B RECEPTOR AGONIST AND 5HT4 SEROTONIN RECEPTOR COMPOSITIONS FOR TREATING GASTROINTESTINAL MOTILITY DISORDERS
  申请人：Brooks Gregory F.

  公开号：US20080153825A1

  公开（公告）日：2008-06-26

  Disclosed herein is a pharmaceutical composition comprising a 5-HT4 serotonin receptor agonist and an alpha-2B receptor agonist. The composition is effective for treating gastrointestinal motility disorders, and methods of treating such disorders using the composition and compounds comprising it are also disclosed.
• ALPHA-2B RECEPTOR AGONIST AND ANTICONVULSANT COMPOSITIONS FOR TREATING CHRONIC PAIN
  申请人：Gil Daniel W.

  公开号：US20080153874A1

  公开（公告）日：2008-06-26

  Disclosed herein is a pharmaceutical composition comprising a pain-relieving anticonvulsant and an alpha-2B receptor agonist. The composition is effective for treating chronic pain, and methods of treating chronic pain using the composition and the compounds comprising it are also disclosed.