[3-(Methoxymethoxy)-5-prop-2-ynoxyphenyl]methanol | 1392500-09-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: [3-(Methoxymethoxy)-5-prop-2-ynoxyphenyl]methanol
• CAS: 1392500-09-2
• 化学式: C₁₂H₁₄O₄
• 分子量: 222.241
• InChiKey: HVQNRUCGQRYYLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [3-(Methoxymethoxy)-5-prop-2-ynoxyphenyl]methanol 在 2,6-二甲基吡啶 、 四溴化碳 、 sodium hydride 、 三苯基膦 作用下， 以 四氢呋喃 、 二氯甲烷 、 mineral oil 为溶剂， 反应 8.67h， 生成 (E)-5-(3-(methoxymethoxy)-5-(prop-2-ynyloxy)styryl)benzo[d][1,3]dioxole
  参考文献：
  名称：

  Synthesis and evaluation of water-soluble resveratrol and piceatannol via BGLation

  摘要：

  Synthesis of four water-soluble resveratrol and piceatannol derivatives bearing symmetrically branched glyceryl trimer (BGL003) with a non-biocleavable linkage, and their biological evaluation as a mitochondrial fusion-inducing agent with cellular fat-reducing effect from cells, is described. The effect of Piceatannol-BGL003 conjugate was as high as that of original stilbenoids. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.06.019
• 作为产物：
  描述：

  3-溴丙炔 、 3-methoxymethyloxy-5-hydroxybenzyl alcohol 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 4.0h， 生成 [3-(Methoxymethoxy)-5-prop-2-ynoxyphenyl]methanol
  参考文献：
  名称：

  Synthesis and evaluation of water-soluble resveratrol and piceatannol via BGLation

  摘要：

  Synthesis of four water-soluble resveratrol and piceatannol derivatives bearing symmetrically branched glyceryl trimer (BGL003) with a non-biocleavable linkage, and their biological evaluation as a mitochondrial fusion-inducing agent with cellular fat-reducing effect from cells, is described. The effect of Piceatannol-BGL003 conjugate was as high as that of original stilbenoids. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.06.019

文献信息

• Synthesis and evaluation of water-soluble resveratrol and piceatannol via BGLation
  作者：Hisao Nemoto、Ayato Katagiri、Masaki Kamiya、Tsuyoshi Matsushita、Hatsuhiko Hattori、Kosuke Matsumura、Tomohiro Itou、Tomoyuki Kawamura、Toshiyuki Kita、Hana Nishida、Naokatu Arakaki

  DOI：10.1016/j.bmcl.2012.06.019

  日期：2012.8

  Synthesis of four water-soluble resveratrol and piceatannol derivatives bearing symmetrically branched glyceryl trimer (BGL003) with a non-biocleavable linkage, and their biological evaluation as a mitochondrial fusion-inducing agent with cellular fat-reducing effect from cells, is described. The effect of Piceatannol-BGL003 conjugate was as high as that of original stilbenoids. (C) 2012 Elsevier Ltd. All rights reserved.