(E)-1,2-bis(methoxymethoxy)-4-(3-(methoxymethoxy)-5-(prop-2-ynyloxy)styryl)benzene | 1392500-12-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E)-1,2-bis(methoxymethoxy)-4-(3-(methoxymethoxy)-5-(prop-2-ynyloxy)styryl)benzene
• 英文别名: 1,2-bis(methoxymethoxy)-4-[(E)-2-[3-(methoxymethoxy)-5-prop-2-ynoxyphenyl]ethenyl]benzene
• CAS: 1392500-12-7
• 化学式: C₂₃H₂₆O₇
• 分子量: 414.455
• InChiKey: KABYQNSWTWNADB-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  30
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  64.6
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-叠氮基-1,3-双[(2,2-二甲基-1,3-二恶烷-5-基)氧代]丙烷 、 (E)-1,2-bis(methoxymethoxy)-4-(3-(methoxymethoxy)-5-(prop-2-ynyloxy)styryl)benzene 在 甲醇 、 copper(ll) sulfate pentahydrate 、 sodium ascorbate 作用下， 以 水 、 叔丁醇 为溶剂， 反应 41.0h， 生成 (E)-2,2'-(2-(4-((3-(3,4-dihydroxystyryl)-5-hydroxyphenoxy)methyl)-1H-1,2,3-triazol-1-yl)propane-1,3-diyl)bis(oxy)dipropane-1,3-diol
  参考文献：
  名称：

  Synthesis and evaluation of water-soluble resveratrol and piceatannol via BGLation

  摘要：

  Synthesis of four water-soluble resveratrol and piceatannol derivatives bearing symmetrically branched glyceryl trimer (BGL003) with a non-biocleavable linkage, and their biological evaluation as a mitochondrial fusion-inducing agent with cellular fat-reducing effect from cells, is described. The effect of Piceatannol-BGL003 conjugate was as high as that of original stilbenoids. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.06.019
• 作为产物：
  描述：

  3-methoxymethyloxy-5-hydroxybenzyl alcohol 在 2,6-二甲基吡啶 、 四溴化碳 、 sodium hydride 、 potassium carbonate 、 三苯基膦 作用下， 以 四氢呋喃 、 二氯甲烷 、 丙酮 、 mineral oil 为溶剂， 反应 10.67h， 生成 (E)-1,2-bis(methoxymethoxy)-4-(3-(methoxymethoxy)-5-(prop-2-ynyloxy)styryl)benzene
  参考文献：
  名称：

  Synthesis and evaluation of water-soluble resveratrol and piceatannol via BGLation

  摘要：

  Synthesis of four water-soluble resveratrol and piceatannol derivatives bearing symmetrically branched glyceryl trimer (BGL003) with a non-biocleavable linkage, and their biological evaluation as a mitochondrial fusion-inducing agent with cellular fat-reducing effect from cells, is described. The effect of Piceatannol-BGL003 conjugate was as high as that of original stilbenoids. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.06.019

文献信息

• Synthesis and evaluation of water-soluble resveratrol and piceatannol via BGLation
  作者：Hisao Nemoto、Ayato Katagiri、Masaki Kamiya、Tsuyoshi Matsushita、Hatsuhiko Hattori、Kosuke Matsumura、Tomohiro Itou、Tomoyuki Kawamura、Toshiyuki Kita、Hana Nishida、Naokatu Arakaki

  DOI：10.1016/j.bmcl.2012.06.019

  日期：2012.8

  Synthesis of four water-soluble resveratrol and piceatannol derivatives bearing symmetrically branched glyceryl trimer (BGL003) with a non-biocleavable linkage, and their biological evaluation as a mitochondrial fusion-inducing agent with cellular fat-reducing effect from cells, is described. The effect of Piceatannol-BGL003 conjugate was as high as that of original stilbenoids. (C) 2012 Elsevier Ltd. All rights reserved.