(E)-(S)-2-tert-Butyl-2-methyl-4-phenyl-but-3-en-1-ol | 140458-20-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂醇
• 英文名称: (E)-(S)-2-tert-Butyl-2-methyl-4-phenyl-but-3-en-1-ol
• CAS: 140458-20-4
• 化学式: C₁₅H₂₂O
• 分子量: 218.339
• InChiKey: ZYBMEFIBSAZILG-AUECHBEKSA-N

反应信息

• 作为产物：
  描述：

  叔丁基锂 、 alkaline earth salt of/the/ methylsulfuric acid 生成 (E)-(S)-2-tert-Butyl-2-methyl-4-phenyl-but-3-en-1-ol 、 (E)-(S)-2-tert-Butyl-2-methyl-4-phenyl-but-3-enoic acid ((S)-1-phenyl-ethyl)-amide
  参考文献：
  名称：

  Nucleophilic addition to vinylketenimine complexes. The asymmetric synthesis of carbon quaternary centres

  摘要：

  Addition of alkyl-lithium reagents to (vinylketenimine)tricarbonyliron(0) complexes generates compounds containing carbon quaternary centres. The major products from these reactions are either amides or aldehydes depending upon the conditions employed. Diastereomerically pure vinylketenimine complexes 7 and 8 of known absolute configuration were synthesised from (S)-alpha-methylbenzylisonitrile 6 (96% e.e.) and the (vinylketene)tricarbonyliron(0) complex 2. The addition of alkyl-lithium reagents to 7 and 8 occurred exclusively exo to the Fe(CO)3 group and the resulting compounds, which contained chiral quaternary centres, were found to be of high optical purity.

  DOI：

  10.1016/s0957-4166(00)82321-6