4,4-二氟-2-己酮 | 86154-55-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 4,4-二氟-2-己酮
• 英文名称: 4,4-difluoro-2-hexanone
• 英文别名: 4,4-difluorohexan-2-one
• CAS: 86154-55-4
• 化学式: C₆H₁₀F₂O
• 分子量: 136.142
• InChiKey: MRCMIUQTTVTYKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2914700090

反应信息

• 作为产物：
  描述：

  2,4-己二酮 以25%的产率得到
  参考文献：
  名称：

  STEPANOV, I. V.;BURMAKOV, A. I.;KUNSHENKO, B. V.;ALEKSEEVA, L. A.;YAGUPOL+, ZH. ORGAN. XIMII, 1983, 19, N 2, 273-279

  摘要：

  DOI：

文献信息

• BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND
  申请人：MITSUBISHI TANABE PHARMA CORPORATION

  公开号：US20190185479A1

  公开（公告）日：2019-06-20

  The present invention provides: a novel use of a specific bicyclic nitrogen-containing heterocyclic compound as a PDE7 inhibitor; a novel bicyclic nitrogen-containing heterocyclic compound having a PDE7 inhibitory effect, a method for producing the compound, a use of the compound, and a pharmaceutical composition containing the PDE7 inhibitor or the compound; and others. More specifically, the present invention provides a PDE7 inhibitor containing the compound represented by the formula (I): [wherein the symbols have the same meanings as those described in the description] or a pharmaceutically acceptable salt thereof as an active ingredient.

  本发明提供了：一种将特定的双环氮杂环化合物用作PDE7抑制剂的新用途；具有PDE7抑制作用的新型双环氮杂环化合物，一种制备该化合物的方法，该化合物的用途，以及含有PDE7抑制剂或该化合物的药物组合物；等等。更具体地，本发明提供了一种包含由下式（I）表示的化合物的PDE7抑制剂： [其中符号的含义与描述中所述的相同]或其药学上可接受的盐作为活性成分。
• Stepanov, I. V.; Burmakov, A. I.; Kunshenko, B. V., Journal of Organic Chemistry USSR (English Translation), 1983, vol. 19, p. 244 - 248
  作者：Stepanov, I. V.、Burmakov, A. I.、Kunshenko, B. V.、Alekseeva, L. A.、Yagupol'skii, L. M.

  DOI：——

  日期：——
• Extended Triterpene Derivatives
  申请人：Myrexis, Inc.

  公开号：US20170096446A1

  公开（公告）日：2017-04-06

  The present invention concerns novel pharmaceutically active triterpene derivatives, pharmaceutical compositions containing the same, their use as medicaments, and the use of the compounds for the manufacture of specific medicaments. The present invention also concerns a method of treatment involving administration of the compounds. Specifically, the compounds are derivatives of betulinic acid having substitutions at one or more of the C-3, C2-8 and C-19 positions as further described herein. The novel compounds are useful as antiretroviral agents. In particular, the novel compounds are useful for the treatment of Human Immunodeficiency Virus (HIV).
• US9505800B2
  申请人：——

  公开号：US9505800B2

  公开（公告）日：2016-11-29
• STEPANOV, I. V.;BURMAKOV, A. I.;KUNSHENKO, B. V.;ALEKSEEVA, L. A.;YAGUPOL+, ZH. ORGAN. XIMII, 1983, 19, N 2, 273-279
  作者：STEPANOV, I. V.、BURMAKOV, A. I.、KUNSHENKO, B. V.、ALEKSEEVA, L. A.、YAGUPOL+

  DOI：——

  日期：——