4-hydroxy-3-{(E)-3-[2-hydroxy-4-(N,N-diethylamino)phenyl]prop-2-enoyl}-1-methylquinone-2 | 1245559-41-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 4-hydroxy-3-{(E)-3-[2-hydroxy-4-(N,N-diethylamino)phenyl]prop-2-enoyl}-1-methylquinone-2
• 英文别名: 4-hydroxy-3-{(E)-3-[2-hydroxy-4-(N,N-diethylamino)phenyl]prop-2-enoyl}-1-methyl-1H-quinolin-2-one；3-[(E)-3-[4-(diethylamino)-2-hydroxyphenyl]prop-2-enoyl]-4-hydroxy-1-methylquinolin-2-one
• CAS: 1245559-41-4
• 化学式: C₂₃H₂₄N₂O₄
• 分子量: 392.455
• InChiKey: FYPWTISHYQBGIA-ACCUITESSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  81.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-{(E)-3-[2-hydroxy-4-(N,N-diethylaminol)-phenyl]prop-2-enoyl}-4-difluoroboronoxy-1-methylquinone-2 在 水 、 sodium carbonate 作用下， 以 乙醇 为溶剂， 以80%的产率得到4-hydroxy-3-{(E)-3-[2-hydroxy-4-(N,N-diethylamino)phenyl]prop-2-enoyl}-1-methylquinone-2
  参考文献：
  名称：

  2-Quinolone and coumarin polymethines for the detection of proteins using fluorescence

  摘要：

  A series of novel, polymethine chalcone dye - 2-quinolone derivatives and their boron difluoride complexes were synthesized. The spectral-luminescence properties of a series of 2-quinolones and their coumarin analogues were characterized in the presence of a denaturing agent (sodium dodecyl sulfate), native bovine serum albumin as well as a combination of serum albumin and sodium dodecyl sulfate. A study of the influence of the BF(2)-ether group on the sensitivity of the polymethine dyes to proteins revealed that three of the dyes, namely two hydroxyquinoline dyes containing a 4-diethylamino-2-hydroxyphenyl substituent and a coumarine dye that contained an indolenine substituent, displayed high emission and bright fluorescence (quantum yield <= 0.27) and thus offer promise for use in protein detection. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2009.07.009