3-(1H-benzo[d]imidazol-2-yl)-6,7-difluoroquinolin-2(1H)-one | 1562415-07-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-(1H-benzo[d]imidazol-2-yl)-6,7-difluoroquinolin-2(1H)-one
• 英文别名: 3-(1H-benzimidazol-2-yl)-6,7-difluoro-1H-quinolin-2-one
• CAS: 1562415-07-9
• 化学式: C₁₆H₉F₂N₃O
• 分子量: 297.264
• InChiKey: VAYAAIVUOPGJRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  57.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6,7-difluoro-2-oxo-quinoline-3-carbaldehyde 、 邻苯二胺 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以65%的产率得到3-(1H-benzo[d]imidazol-2-yl)-6,7-difluoroquinolin-2(1H)-one
  参考文献：
  名称：

  Spectroscopic study of the recognition of 2-quinolinone derivative on mercury ion

  摘要：

  A new compound based on 2-quinolinone derivative with very little side effects on organisms, 3-(1H-benzo[d]imidazol-2-yl)-6,7-difluoroquinolin-2(1H)-one, has been designed, synthesized and characterized. And its recognition ability was firstly studied by spectroscopy. The result indicated that the compound shows high selectivity for Hg2+ over other metal ions with detectable fluorescent signals in aqueous-methanol media. The proposed mechanism is that the fluorescence of the probe was quenched due to the effect from spin-orbit coupling of Hg2+ after the probe coordinated with Hg2+, and was proved by ESI-MS and H-1 NMR analysis. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2014.04.044

文献信息

• Quinolinone derivatives
  申请人：Renhowe A. Paul

  公开号：US20050209456A1

  公开（公告）日：2005-09-22

  A method for synthesizing a 4-amino substituted quinolinone includes reacting a substituted or unsubstituted 2-benzimidazolyl-2-acetate with a substituted or unsubstituted 2-aminobenzonitrile in the presence of a base or an acid. A 4-amino substituted quinolinone compound is formed by the reaction, and the 4-amino substituted quinolinone compound comprises a benzimidazole group.

  一种合成4-氨基取代喹啉酮的方法，包括在碱或酸的存在下，将取代或未取代的2-苯并咪唑-2-乙酸酯与取代或未取代的2-氨基苯甲腈反应。反应生成4-氨基取代喹啉酮化合物，并且该4-氨基取代喹啉酮化合物包含苯并咪唑基团。
• QUINOLINONE DERIVATIVES
  申请人：Renhowe A. Paul

  公开号：US20080070906A1

  公开（公告）日：2008-03-20

  Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.

  提供了具有I和II公式的有机化合物，其中变量具有所述数值。制药配方包括有机化合物或其药学上可接受的盐以及药学上可接受的载体，并且可以通过将有机化合物或其药学上可接受的盐与载体和水混合来制备。治疗患者的方法包括向需要该药物的患者注射本发明的制药配方。
• US6605617B2
  申请人：——

  公开号：US6605617B2

  公开（公告）日：2003-08-12
• US6762194B2
  申请人：——

  公开号：US6762194B2

  公开（公告）日：2004-07-13
• US6774237B2
  申请人：——

  公开号：US6774237B2

  公开（公告）日：2004-08-10