N-acetyl-L-isoleucyl-O-benzyl-L-tyrosyl-O-benzyl-L-tyrosine benzyl ester | 1039759-57-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-acetyl-L-isoleucyl-O-benzyl-L-tyrosyl-O-benzyl-L-tyrosine benzyl ester
• CAS: 1039759-57-3
• 化学式: C₄₇H₅₁N₃O₇
• 分子量: 769.938
• InChiKey: DQJQJKPBEODWGF-CNVJWQCBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.89
• 重原子数：
  57.0
• 可旋转键数：
  20.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  132.06
• 氢给体数：
  3.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  N-acetyl-L-isoleucyl-O-benzyl-L-tyrosyl-O-benzyl-L-tyrosine benzyl ester 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 以86.8%的产率得到N-acetyl-L-isoleucyl-L-tyrosyl-L-tyrosine
  参考文献：
  名称：

  Identification of ACE pharmacophore in the phosphonopeptide metabolite K-26

  摘要：

  The naturally occurring phosphonotripeptide K-26 is a potent angiotensin converting enzyme (ACE) inhibitor containing an alpha-amino phosphonic acid analogue of tyrosine. Previous studies have demonstrated that canonical peptide analogues of K-26 are micromolar inhibitors of ACE. To ascertain the structure-activity relationships in this class of ACE inhibitory natural products, K-26 and eight analogues were chemically synthesized and evaluated. Phosphonyl substitution was found to be the critical determinant of activity, resulting in a 1500-fold increase in ACE inhibition versus carboxyl analogues. Secondarily, the absolute configuration of the terminal alpha-amino phosphonate and N-acetylation were found to significantly modulate ACE inhibitory activity. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.11.130
• 作为产物：
  描述：

  N-acetyl-L-isoleucyl-O-benzyl-L-tyrosine 、 O-苄基-L-酪氨酸苄酯盐酸盐 在 2,4,6-三甲基吡啶 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以82.3%的产率得到N-acetyl-L-isoleucyl-O-benzyl-L-tyrosyl-O-benzyl-L-tyrosine benzyl ester
  参考文献：
  名称：

  Identification of ACE pharmacophore in the phosphonopeptide metabolite K-26

  摘要：

  The naturally occurring phosphonotripeptide K-26 is a potent angiotensin converting enzyme (ACE) inhibitor containing an alpha-amino phosphonic acid analogue of tyrosine. Previous studies have demonstrated that canonical peptide analogues of K-26 are micromolar inhibitors of ACE. To ascertain the structure-activity relationships in this class of ACE inhibitory natural products, K-26 and eight analogues were chemically synthesized and evaluated. Phosphonyl substitution was found to be the critical determinant of activity, resulting in a 1500-fold increase in ACE inhibition versus carboxyl analogues. Secondarily, the absolute configuration of the terminal alpha-amino phosphonate and N-acetylation were found to significantly modulate ACE inhibitory activity. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.11.130