1-methyl-3-methylsulphinyl-7-trifluoromethyl-4-quinolone | 76568-25-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-methyl-3-methylsulphinyl-7-trifluoromethyl-4-quinolone
• 英文别名: 1-methyl-3-methylsulfinyl-7-(trifluoromethyl)quinolin-4-one
• CAS: 76568-25-7
• 化学式: C₁₂H₁₀F₃NO₂S
• 分子量: 289.278
• InChiKey: FCLWUYJURISLKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  56.6
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  1-methyl-3-methylsulphinyl-7-trifluoromethyl-4-quinolone 生成 1-methyl-3-methylsulphonyl-7-trifluoromethyl-4-quinolone
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  1-methyl-3-methylthio-7-trifluoromethyl-4-quinolone 生成 1-methyl-3-methylsulphinyl-7-trifluoromethyl-4-quinolone
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• 4-Quinolinones having antihypertensive activity
  申请人：The Boots Company Limited

  公开号：US04302460A1

  公开（公告）日：1981-11-24

  Compositions which contain a quinolone compound of the general formula ##STR1## wherein n is 0, 1 or 2; R.sub.1 is lower alkyl optionally substituted by hydroxy or C.sub.1-4 alkoxycarbonyl; allyl; propynyl or phenyl- lower alkyl in which the phenyl ring is optionally substituted by 1 or 2 C.sub.1-4 alkoxy groups; R.sub.2 is C.sub.1-4 alkyl with the proviso that when n is 0, R.sub.2 is methyl; and R.sub.3, R.sub.4 and R.sub.5, which may be the same or different, are hydrogen, lower alkyl, lower alkoxy, lower alkanoyl, halo, trifluoromethyl or lower alkylthio show antihypertensive activity. Compounds of general formula ##STR2## in which n, R.sub.1 R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as described above are novel subject to the following provisos (a) when R.sub.3, R.sub.4 and R.sub.4 and R.sub.5 are hydrogen R.sub.2 is methyl and R.sub.1 is lower alkyl, R.sub.1 contains more than one carbon atom, and (b) when R.sub.3 and R.sub.4 are hydrogen, R.sub.5 is hydrogen or 7-methyl, and R.sub.1 is ethyl, R.sub.2 contains more than one carbon atom. The specification describes and claims methods of making the compounds and novel intermediates used in such methods.

  含有通式 ##STR1## 中喹诺酮化合物的组合物，其中n为0、1或2；R.sub.1是低碳基，可选地被羟基或C.sub.1-4烷氧羰基取代；烯丙基；丙炔基或苯基-低碳基，其中苯环可选地被1或2个C.sub.1-4烷氧基取代；R.sub.2是C.sub.1-4烷基，但当n为0时，R.sub.2为甲基；R.sub.3，R.sub.4和R.sub.5，它们可以相同也可以不同，是氢、低碳基、低烷氧基、低烷酰基、卤素、三氟甲基或低碳硫基，具有降压活性。通式 ##STR2## 中的化合物，其中n、R.sub.1、R.sub.2、R.sub.3、R.sub.4和R.sub.5如上所述，但受以下限制：(a)当R.sub.3、R.sub.4和R.sub.5为氢时，R.sub.2为甲基，R.sub.1为低碳基，R.sub.1含有多于一个碳原子；(b)当R.sub.3和R.sub.4为氢时，R.sub.5为氢或7-甲基，R.sub.1为乙基，R.sub.2含有多于一个碳原子。该说明书描述和声明了制备这些化合物和用于这些方法的新型中间体的方法。
• Use of quinolones for the manufacture of a composition for the treatment of heart failure.
  申请人：The Boots Company PLC

  公开号：EP0149519A2

  公开（公告）日：1985-07-24

  The use of quinolones of the formula I wherein m is 0 or 1; n is 0, 1 or 2; and R is hydrogen, halo, methyl or trifluoromethyl for the treatment of heart failure. A preferred use is the treatment of chronic heart failure by oral administration of the quinolones of formula I. Preferred compounds of formula I are 7-fluoro-1-methyl-3-methylsulphinyl-4-quinolone and 1-methyl-3-methylsulphonylmethyl-4-quinolone.

  式 I 中 m 为 0 或 1；n 为 0、1 或 2；R 为氢、卤素、甲基或三氟甲基的喹诺酮类药物用于治疗心力衰竭。 优选的式 I 化合物是 7-氟-1-甲基-3-甲基磺酰基-4-喹诺酮和 1-甲基-3-甲基磺酰基甲基-4-喹诺酮。
• ——
  作者：

  DOI：——

  日期：——
• US4302460A
  申请人：——

  公开号：US4302460A

  公开（公告）日：1981-11-24
• US4552884A
  申请人：——

  公开号：US4552884A

  公开（公告）日：1985-11-12