4-(2-fluoro-4-methoxyphenyl)-1H-imidazole | 1314984-63-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(2-fluoro-4-methoxyphenyl)-1H-imidazole
• 英文别名: 5-(2-fluoro-4-methoxyphenyl)-1H-imidazole
• CAS: 1314984-63-8
• 化学式: C₁₀H₉FN₂O
• mdl: MFCD08669179
• 分子量: 192.193
• InChiKey: CRBYKEOMUWIGGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  37.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(2-fluoro-4-methoxyphenyl)-1H-imidazole 、 2-(三甲基硅烷基)乙氧甲基氯 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Structure–activity relationships of 2,4-diphenyl-1H-imidazole analogs as CB2 receptor agonists for the treatment of chronic pain

  摘要：

  A series of 2,4-diphenyl-1H-imidazole analogs have been synthesized and displayed potent human CB2 agonist activity. Many of these analogs showed high functional selectivity over human CB1 receptors. The syntheses, structure-activity relationships, and selected pharmacokinetic data of these analogs are described. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.11.044
• 作为产物：
  描述：

  2-溴-2’-氟-4’-甲氧基苯乙酮 、 formamide 反应 2.0h， 生成 4-(2-fluoro-4-methoxyphenyl)-1H-imidazole
  参考文献：
  名称：

  Structure–activity relationships of 2,4-diphenyl-1H-imidazole analogs as CB2 receptor agonists for the treatment of chronic pain

  摘要：

  A series of 2,4-diphenyl-1H-imidazole analogs have been synthesized and displayed potent human CB2 agonist activity. Many of these analogs showed high functional selectivity over human CB1 receptors. The syntheses, structure-activity relationships, and selected pharmacokinetic data of these analogs are described. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.11.044

文献信息

• Structure–activity relationships of 2,4-diphenyl-1H-imidazole analogs as CB2 receptor agonists for the treatment of chronic pain
  作者：Shu-Wei Yang、Jennifer Smotryski、Julius Matasi、Ginny Ho、Deen Tulshian、William J. Greenlee、Rossella Brusa、Massimiliano Beltramo、Kathleen Cox

  DOI：10.1016/j.bmcl.2010.11.044

  日期：2011.1

  A series of 2,4-diphenyl-1H-imidazole analogs have been synthesized and displayed potent human CB2 agonist activity. Many of these analogs showed high functional selectivity over human CB1 receptors. The syntheses, structure-activity relationships, and selected pharmacokinetic data of these analogs are described. (C) 2010 Elsevier Ltd. All rights reserved.