methyl O-(2,3-di-O-benzoyl-4,6-O-benzylidene-α-D-mannopyranosyl)-(1->3)-2-O-benzyl-4,6-O-benzylidene-α-D-mannopyranoside | 187159-75-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl O-(2,3-di-O-benzoyl-4,6-O-benzylidene-α-D-mannopyranosyl)-(1->3)-2-O-benzyl-4,6-O-benzylidene-α-D-mannopyranoside
• CAS: 187159-75-7
• 化学式: C₄₈H₄₆O₁₃
• 分子量: 830.885
• InChiKey: OGDPNARUBDBRTN-HIYZXVQSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.73
• 重原子数：
  61.0
• 可旋转键数：
  12.0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  135.67
• 氢给体数：
  0.0
• 氢受体数：
  13.0

反应信息

• 作为反应物：
  描述：

  methyl O-(2,3-di-O-benzoyl-4,6-O-benzylidene-α-D-mannopyranosyl)-(1->3)-2-O-benzyl-4,6-O-benzylidene-α-D-mannopyranoside 在 4 A molecular sieve 、 sodium methylate 、 二正丁基氧化锡 、 DMTST 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 0.5h， 生成 methyl O-(2,3-di-O-benzoyl-4,6-O-benzylidene-α-D-mannopyranosyl)-(1->3)-O-(4,6-O-benzylidene-α-D-mannopyranosyl)-(1->3)-2-O-benzyl-4,6-O-benzylidene-α-D-mannopyranoside
  参考文献：
  名称：

  Synthesis of oligosaccharides corresponding to structures found in capsular polysaccharides of Cryptococcus neoformans—II

  摘要：

  Formula 1 depicts a generalized structure of the capsular polysaccharides of four serotypes of the opportunistic microorganism Cryptococcus neoformans, which appears as one of the major infections in the late stages of development of AIDS. Syntheses are now described of two tetrasaccharides with corresponding structures. These are methyl O-alpha-D-mannopyranosyl-(1-->3)-[O-beta-D-xylopyranosyl-(1-->2)]-O-alpha-D-mannopyranosyl-(1-->3)-alpha-D-mannopyranoside and methyl O-alpha-D-mannopyranosyl-(1-->3)-[O-beta-D-glucopyranosyluronic acid-(1-->2)]-O-alpha-D-mannopyranosyl-(1-->3)-alpha-D-mannopyranoside. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0968-0896(96)00168-x
• 作为产物：
  描述：

  methyl 2-O-benzyl-(R)-4,6-O-benzylidene-α-D-mannopyranoside 、 ethyl 2,3-di-O-benzoyl-4,6-O-benzylidene-1-thio-α-D-mannopyranoside 在 4 A molecular sieve 、 DMTST 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以87%的产率得到methyl O-(2,3-di-O-benzoyl-4,6-O-benzylidene-α-D-mannopyranosyl)-(1->3)-2-O-benzyl-4,6-O-benzylidene-α-D-mannopyranoside
  参考文献：
  名称：

  Synthesis of oligosaccharides corresponding to structures found in capsular polysaccharides of Cryptococcus neoformans—II

  摘要：

  Formula 1 depicts a generalized structure of the capsular polysaccharides of four serotypes of the opportunistic microorganism Cryptococcus neoformans, which appears as one of the major infections in the late stages of development of AIDS. Syntheses are now described of two tetrasaccharides with corresponding structures. These are methyl O-alpha-D-mannopyranosyl-(1-->3)-[O-beta-D-xylopyranosyl-(1-->2)]-O-alpha-D-mannopyranosyl-(1-->3)-alpha-D-mannopyranoside and methyl O-alpha-D-mannopyranosyl-(1-->3)-[O-beta-D-glucopyranosyluronic acid-(1-->2)]-O-alpha-D-mannopyranosyl-(1-->3)-alpha-D-mannopyranoside. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0968-0896(96)00168-x