(2R,3S,4R,5R,6R)-2-(acetoxymethyl)-6-((12-azidododecyl)oxy)-5-(5,6-dichloro-1,3-dioxoisoindolin-2-yl)tetrahydro-2H-pyran-3,4-diyl diacetate | 1036637-17-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3S,4R,5R,6R)-2-(acetoxymethyl)-6-((12-azidododecyl)oxy)-5-(5,6-dichloro-1,3-dioxoisoindolin-2-yl)tetrahydro-2H-pyran-3,4-diyl diacetate
• CAS: 1036637-17-8
• 化学式: C₃₂H₄₂Cl₂N₄O₁₀
• 分子量: 713.612
• InChiKey: UIHBCSACDOCTBJ-VPNCTUESSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.34
• 重原子数：
  48.0
• 可旋转键数：
  19.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.66
• 拓扑面积：
  183.5
• 氢给体数：
  0.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  (2R,3S,4R,5R,6R)-2-(acetoxymethyl)-6-((12-azidododecyl)oxy)-5-(5,6-dichloro-1,3-dioxoisoindolin-2-yl)tetrahydro-2H-pyran-3,4-diyl diacetate 在 乙二胺 作用下， 以 甲醇 为溶剂， 反应 18.0h， 生成
  参考文献：
  名称：

  Chemical and enzymatic synthesis of neoglycolipids in the presence of cyclodextrins

  摘要：

  The efficiency of cyclodextrins (CDs), alpha-CD, beta-CD and gamma-CD, for the blotting of hydrophobic substrates to water-soluble polymers and for the synthesis of neoglycolipids using glycosyltransferase is described. CDs did not disturb HPLC purification and did not bring lather. These merits are superior to surfactants commonly used in such a case. The utility of CDs as a novel and efficient supporting material for enzymatic glycosylation is also discussed. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.03.103
• 作为产物：
  描述：

  3,4,6-tri-O-acetyl-2-(4,5-dichlorophthalimido)-2-deoxy-D-glucopyranosyl bromide 、 12-叠氮-1-十二醇,12-AZIDO-1-DODECANOL 在 2,4,6-三甲基吡啶 、 silver trifluoromethanesulfonate 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以59%的产率得到(2R,3S,4R,5R,6R)-2-(acetoxymethyl)-6-((12-azidododecyl)oxy)-5-(5,6-dichloro-1,3-dioxoisoindolin-2-yl)tetrahydro-2H-pyran-3,4-diyl diacetate
  参考文献：
  名称：

  Chemical and enzymatic synthesis of neoglycolipids in the presence of cyclodextrins

  摘要：

  The efficiency of cyclodextrins (CDs), alpha-CD, beta-CD and gamma-CD, for the blotting of hydrophobic substrates to water-soluble polymers and for the synthesis of neoglycolipids using glycosyltransferase is described. CDs did not disturb HPLC purification and did not bring lather. These merits are superior to surfactants commonly used in such a case. The utility of CDs as a novel and efficient supporting material for enzymatic glycosylation is also discussed. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.03.103