2-oxo-quinoline-3-carbaldehyde(nicotinoyl)hydrazone | 879202-56-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-oxo-quinoline-3-carbaldehyde(nicotinoyl)hydrazone
• 英文别名: N-[(2-oxo-1H-quinolin-3-yl)methylideneamino]pyridine-3-carboxamide
• CAS: 879202-56-9
• 化学式: C₁₆H₁₂N₄O₂
• 分子量: 292.297
• InChiKey: HDRDPFOOZAYMQV-UHFFFAOYSA-N

物化性质

• 密度：
  1.34±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  aluminium trinitrate 、 2-oxo-quinoline-3-carbaldehyde(nicotinoyl)hydrazone 以 乙醇 为溶剂， 反应 0.05h， 生成
  参考文献：
  名称：

  A highly selective chemosensor for Al3+ based on 2-oxo-quinoline-3-carbaldehyde Schiff-base

  摘要：

  A new Schiff-base ligand (1) with good fluorescence response to Al3+, derived from 2-oxo-quinoline-3-carbaldehyde and nicotinic hydrazide, had been synthesized and investigated in this paper. Spectroscopic investigation revealed that the compound I exhibited a high selectivity and sensitivity toward Al(III) ions over other commonly coexisting metal ions in ethanol, and the detection limit of Al3+ ions is at the parts per billion level. The mass spectra and Job's plot confirmed the 1:1 stoichiometry between 1 and Al3+. Potential utilization of 1 as intracellular sensors of Al3+ ions in human cancer (HeLa) cells was also examined by confocal fluorescence microscopy. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2013.12.076
• 作为产物：
  描述：

  N-乙酰苯胺 在 三氯氧磷 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 2-oxo-quinoline-3-carbaldehyde(nicotinoyl)hydrazone
  参考文献：
  名称：

  A highly selective chemosensor for Al3+ based on 2-oxo-quinoline-3-carbaldehyde Schiff-base

  摘要：

  A new Schiff-base ligand (1) with good fluorescence response to Al3+, derived from 2-oxo-quinoline-3-carbaldehyde and nicotinic hydrazide, had been synthesized and investigated in this paper. Spectroscopic investigation revealed that the compound I exhibited a high selectivity and sensitivity toward Al(III) ions over other commonly coexisting metal ions in ethanol, and the detection limit of Al3+ ions is at the parts per billion level. The mass spectra and Job's plot confirmed the 1:1 stoichiometry between 1 and Al3+. Potential utilization of 1 as intracellular sensors of Al3+ ions in human cancer (HeLa) cells was also examined by confocal fluorescence microscopy. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2013.12.076

文献信息

• Kumar, M.R. Pradeep; Joshi; Dixit, Indian Journal of Heterocyclic Chemistry, 2014, vol. 23, # 4, p. 353 - 358
  作者：Kumar, M.R. Pradeep、Joshi、Dixit、Kulkarni

  DOI：——

  日期：——