1,18-diazo-octadecane-2,17-dione | 875225-09-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,18-diazo-octadecane-2,17-dione
• 英文别名: 1,18-Diazo-octadecan-2,17-dion
• CAS: 875225-09-5
• 化学式: C₁₈H₃₀N₄O₂
• 分子量: 334.462
• InChiKey: VJIHWGIMONJDMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.19
• 重原子数：
  24.0
• 可旋转键数：
  17.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  106.94
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  1,18-diazo-octadecane-2,17-dione 在 盐酸 、 氯仿 、 溶剂黄146 、 锌 作用下， 生成 2,17-octadecanedione
  参考文献：
  名称：

  Canonica; Bacchetti, Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1953, vol. <8>15, p. 278,281

  摘要：

  DOI：
• 作为产物：
  描述：

  十六碳二酸 在 氯化亚砜 作用下， 生成 1,18-diazo-octadecane-2,17-dione
  参考文献：
  名称：

  Canonica; Bacchetti, Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1953, vol. <8>15, p. 278,281

  摘要：

  DOI：

文献信息

• Gold-catalyzed intramolecular diazo coupling: an efficient macrocyclization towards cyclic olefins
  作者：Chenghao Zhu、Guangyang Xu、Kai Liu、Lin Qiu、Shiyong Peng、Jiangtao Sun

  DOI：10.1039/c5cc04830c

  日期：——

  A gold-catalyzed synthesis of medium to large membered cyclic olefins has been developed.

  一种利用金催化的合成中等到大环烯烃的方法已经开发出来了。
• A New General Route to Thiophenophanes:  Synthesis and Properties of [<i>n</i>](2,5)Thiophenophane-1,<i>n</i>-diones
  作者：Yuji Miyahara

  DOI：10.1021/jo060889n

  日期：2006.8.1

  A series of [ n]( 2,5) thiophenophane-1, n-diones ( 5) ( n = 9, 10, 12, 14, 16, and 20) were synthesized in a simple four-step route starting from the appropriate 1,omega-oligomethylenedicarboxylic acids. The bis-( halomethylketones) ( 6), which were obtained by successive treatment of the diacids with SOCl2, diazomethane, and HBr or HCl, were cyclized by Na2S under high dilution conditions. The obtained monomeric cyclic diketosulfides ( 4) were condensed with glyoxal in MeOH by slowly adding dilute NaOMe affording 5. The thiophene-2,5-dicarbonyl moiety of 5 ( n = 9) is significantly deformed as shown by X-ray crystallography, and the effect of the strain is reflected in the C=O stretching frequencies and the pi-pi* and the n-pi* absorptions.