1,5-bis(6-bromo-2-pyridyl)-1,5-dioxopentane | 37709-55-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,5-bis(6-bromo-2-pyridyl)-1,5-dioxopentane
• 英文别名: 1,5-di(6-bromo-2-pyridyl)pentane-1,5-dione；1,5-bis-(6-bromo-pyridin-2-yl)-pentane-1,5-dione；1,5-Bis(6-bromo-2-pyridinyl)-1,5-pentanedione；1,5-bis(6-bromopyridin-2-yl)pentane-1,5-dione
• CAS: 37709-55-0
• 化学式: C₁₅H₁₂Br₂N₂O₂
• 分子量: 412.08
• InChiKey: QATDJPCLUQYHJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  59.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,5-bis(6-bromo-2-pyridyl)-1,5-dioxopentane 在 (-)-diisopinocamphenylborane chloride 作用下， 以 四氢呋喃 为溶剂， 以64%的产率得到1,5-di(6-bromo-2-pyridyl)pentane-(1S,5S)-diol
  参考文献：
  名称：

  Detection of Zinc Ions by Differential Circularly Polarized Fluorescence Excitation

  摘要：

  A new chiroptical spectroscopic approach, differential circularly polarized fluorescence excitation (CPE), can be used to provide a selective method for detecting the presence of zinc ions. The approach utilizes the same instrumentation as fluorescence-detected circular dichroism and provides strong contrast in metal detection due to response to both chelation-enhanced fluorescence and circular dichroism upon metal ion binding. The observed contrast is therefore better than either of the parent spectroscopic detection methods. CPE also provides a strategy to reduce interference from background such as protein-based tryptophan fluorescence.

  DOI：

  10.1021/ja047213z
• 作为产物：
  描述：

  戊二酰基二氯 在 吡啶 、 正丁基锂 作用下， 以 乙醚 、 氯仿 为溶剂， 反应 3.5h， 生成 1,5-bis(6-bromo-2-pyridyl)-1,5-dioxopentane
  参考文献：
  名称：

  Detection of Zinc Ions by Differential Circularly Polarized Fluorescence Excitation

  摘要：

  A new chiroptical spectroscopic approach, differential circularly polarized fluorescence excitation (CPE), can be used to provide a selective method for detecting the presence of zinc ions. The approach utilizes the same instrumentation as fluorescence-detected circular dichroism and provides strong contrast in metal detection due to response to both chelation-enhanced fluorescence and circular dichroism upon metal ion binding. The observed contrast is therefore better than either of the parent spectroscopic detection methods. CPE also provides a strategy to reduce interference from background such as protein-based tryptophan fluorescence.

  DOI：

  10.1021/ja047213z

文献信息

• Chemistry of heterocyclic compounds. Part 119. Synthesis of halogenated terpyridines and incorporation of the terpyridine nucleus into a polyetheral macrocycle
  作者：George R. Newkome、David C. Hager、Garry E. Kiefer

  DOI：10.1021/jo00356a019

  日期：1986.3
• NEWKOME, G. R.;HAGER, D. C.;KIEFER, G. E., J. ORG. CHEM., 1986, 51, N 6, 850-853
  作者：NEWKOME, G. R.、HAGER, D. C.、KIEFER, G. E.

  DOI：——

  日期：——