| 1161397-51-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1161397-51-8
• 化学式: C₅₉H₆₈O₉
• 分子量: 921.184
• InChiKey: FLGBEAFEJDGDOS-PMKAOPLHSA-N

反应信息

• 作为反应物：
  描述：

  在 Grubbs catalyst first generation 作用下， 以 二氯甲烷 为溶剂， 以75%的产率得到(1R,3S,6R,7S,9R,11Z,14S,16R,18S,19R,21S,22R)-21-methyl-6,18,22-tris(phenylmethoxy)-7,19-bis(phenylmethoxymethyl)-2,8,15,20-tetraoxatetracyclo[12.9.0.03,9.016,21]tricosa-4,11-diene
  参考文献：
  名称：

  Design and Synthesis of a Conformationally Restricted Analogue of the EFGH-Ring System of Ciguatoxin

  摘要：

  The fused-hexahydrooxonine (F-ring) of ciguatoxin (CTX), as well as its EFGH-ring fragment, undergoes a slow conformational change between two conformers in solution. In this paper, we designed and synthesized a conformationally restricted analogue of the EFGH-ring system of ciguatoxin. Chemo- and stereoselective epoxidation of the F-ring successfully impeded the dynamic behavior without affecting the overall three-dimensional shape of the molecule.

  DOI：

  10.3987/com-08-s(d)7
• 作为产物：
  描述：

  、 甲基三苯基溴化膦 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Design and Synthesis of a Conformationally Restricted Analogue of the EFGH-Ring System of Ciguatoxin

  摘要：

  The fused-hexahydrooxonine (F-ring) of ciguatoxin (CTX), as well as its EFGH-ring fragment, undergoes a slow conformational change between two conformers in solution. In this paper, we designed and synthesized a conformationally restricted analogue of the EFGH-ring system of ciguatoxin. Chemo- and stereoselective epoxidation of the F-ring successfully impeded the dynamic behavior without affecting the overall three-dimensional shape of the molecule.

  DOI：

  10.3987/com-08-s(d)7