Ethyl 5-methylquinoline-2-carboxylate | 1415319-33-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Ethyl 5-methylquinoline-2-carboxylate
• CAS: 1415319-33-3
• 化学式: C₁₃H₁₃NO₂
• 分子量: 215.252
• InChiKey: CUQBKJWUHDGCNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-乙烯基己内酰胺 、 ethyl (meta-methylphenylimino)acetate 在 tris(p-bromophenylammoniumyl) hexachloroantimonate 作用下， 以 1,2-二氯乙烷 为溶剂， 生成 Ethyl 5-methylquinoline-2-carboxylate 、 Ethyl 7-methylquinoline-2-carboxylate
  参考文献：
  名称：

  Radical cation salt induced Povarov reaction between iminoethyl glyoxylate and N-vinylamides: synthesis of quinoline-2-carboxylate derivatives

  摘要：

  A domino process between iminoethyl glyoxylate and N-vinylamides was achieved under the catalytic radical cation salt induced conditions, producing a series of quinoline-2-carboxylates. N-Vinylamides were involved as an acetylene equivalent. A possible mechanism was proposed to rationalize the formation of the products. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.10.097

文献信息

• [EN] 4-HYDROXYQUINOLINE-3-CARBOXAMIDES AND HYDRAZIDES AS ANTIVIRAL AGENTS<br/>[FR] 4-HYDROXYQUINOLINE-3-CARBOXAMIDES ET HYDRAZIDES UTILISES COMME AGENTS ANTIVIRAUX
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：WO1999032450A1

  公开（公告）日：1999-07-01

  (EN) The present invention provides 4-hydroxyquinoline-3-carboxamide and hydrazide compounds of formula (I). These compounds are useful to treat or prevent the herpesviral infections, particularly, human cytomegaloviral infection.(FR) La présente invention concerne des composés de 4-hydroxyquinoline-3-carboxamide et d'hydrazide représentés par la formule (I). Ces composés servent dans le traitement ou la prévention d'infections à virus herpétique, en particulier, de l'infection à cytomégalovirus humain.

  本发明提供了公式（I）的4-羟基喹啉-3-羧酰胺和肼类化合物。这些化合物可用于治疗或预防疱疹病毒感染，特别是人类巨细胞病毒感染。
• 4-HYDROXYQUINOLINE-3-CARBOXAMIDES AND HYDRAZIDES AS ANTIVIRAL AGENTS
  申请人：Pharmacia & Upjohn Company LLC

  公开号：EP1042295B1

  公开（公告）日：2005-09-07
• US6093732A
  申请人：——

  公开号：US6093732A

  公开（公告）日：2000-07-25
• Radical cation salt induced Povarov reaction between iminoethyl glyoxylate and N-vinylamides: synthesis of quinoline-2-carboxylate derivatives
  作者：Xiaodong Jia、Chang Qing、Congde Huo、Fangfang Peng、Xicun Wang

  DOI：10.1016/j.tetlet.2012.10.097

  日期：2012.12

  A domino process between iminoethyl glyoxylate and N-vinylamides was achieved under the catalytic radical cation salt induced conditions, producing a series of quinoline-2-carboxylates. N-Vinylamides were involved as an acetylene equivalent. A possible mechanism was proposed to rationalize the formation of the products. (C) 2012 Elsevier Ltd. All rights reserved.