8-formyl-7-hydroxyl-4-methylcoumarin-(2'-methylquinoline-4-formyl)hydrazone | 1620950-64-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-formyl-7-hydroxyl-4-methylcoumarin-(2'-methylquinoline-4-formyl)hydrazone
• CAS: 1620950-64-2
• 化学式: C₂₂H₁₇N₃O₄
• 分子量: 387.395
• InChiKey: JOJAOSPSKSNPFK-UHFFFAOYSA-N

物化性质

• 熔点：
  283-284 °C
• 密度：
  1.36±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.43
• 重原子数：
  29.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  104.79
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  2-甲基喹啉-4-甲酸 在 硫酸 、 一水合肼 作用下， 以 乙醇 为溶剂， 反应 42.0h， 生成 8-formyl-7-hydroxyl-4-methylcoumarin-(2'-methylquinoline-4-formyl)hydrazone
  参考文献：
  名称：

  Fluorescent sensor for selective detection of Al3+ based on quinoline–coumarin conjugate

  摘要：

  A fluorescence probe, 8-formyl-7-hydroxyl-4-methyl coumarin - (2'-methylquinoline-4-formyl) hydrazone (L) has been synthesized. The chemosensor is found preferential binding to Al3+ in presence of other competitive ions with associated changes in its optical and fluorescence spectra behavior. Upon addition of Al3+ to a solution of L, it shows 200-fold enhancement of fluorescence intensity which might be attributed to form a 2:1 stoichiometry of the binding mode of L-Al(III) and the chelation enhanced fluorescence (CHEF) process at 479 nm in ethanol. The lowest detection limit for Al3+ is determined as 8.2 x 10(-7) M. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2014.05.033