5,10-dihydroxy-3-methylsulfanyl-1H-benzo[g]quinolin-4-one | 1019922-34-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5,10-dihydroxy-3-methylsulfanyl-1H-benzo[g]quinolin-4-one
• CAS: 1019922-34-9
• 化学式: C₁₄H₁₁NO₃S
• 分子量: 273.312
• InChiKey: XCDPSXMLNYOABH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  94.9
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5,10-dihydroxy-3-methylsulfanyl-1H-benzo[g]quinolin-4-one 在 哌啶 、 三乙胺 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 43.0h， 生成
  参考文献：
  名称：

  Poly Fused/Isolated/Spiro Sulphur Compounds of Quinone and Their Biological Activity

  摘要：

  A series of some fused and spiro heterocyclic compounds such as pyrazolines, Isoxazolines, pyrimidines, beta-lactams, and thiazolidinone derivatives 3, 6a-d, 7a-d, 9a-c, 10a-c, 11a-c, 12a-c, 13a-c have been synthesised by cycloaddition and cycloconden-sation reaction of monochloroacetyl chloride, mercaptoacetic acid, hydrazines, hydroxylamine, urea, and thiourea incorporating the prepared compounds 5a-d, 8a-c. The synthesized compounds were tested for antibacterial and fungicidal activity. Gram-negative Bacillus cereus, Gram-negative serratia sp, as well as the fungus were used for this purpose. The biological assay was determined according to the filter paper disc method. Assay plates were incubated at 30 degrees C one day for the bacteria and three dayes for the fungus (British Pharmacopoeia commisson, 1102m, London 1963). The test results show that the components have a strong and satisfactory effect.

  DOI：

  10.1080/10426500701242848
• 作为产物：
  描述：

  5,10-dihydroxy-3-sulfanyl-1H-benzo[g]quinolin-4-one 、 碘甲烷 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 以63%的产率得到5,10-dihydroxy-3-methylsulfanyl-1H-benzo[g]quinolin-4-one
  参考文献：
  名称：

  Poly Fused/Isolated/Spiro Sulphur Compounds of Quinone and Their Biological Activity

  摘要：

  A series of some fused and spiro heterocyclic compounds such as pyrazolines, Isoxazolines, pyrimidines, beta-lactams, and thiazolidinone derivatives 3, 6a-d, 7a-d, 9a-c, 10a-c, 11a-c, 12a-c, 13a-c have been synthesised by cycloaddition and cycloconden-sation reaction of monochloroacetyl chloride, mercaptoacetic acid, hydrazines, hydroxylamine, urea, and thiourea incorporating the prepared compounds 5a-d, 8a-c. The synthesized compounds were tested for antibacterial and fungicidal activity. Gram-negative Bacillus cereus, Gram-negative serratia sp, as well as the fungus were used for this purpose. The biological assay was determined according to the filter paper disc method. Assay plates were incubated at 30 degrees C one day for the bacteria and three dayes for the fungus (British Pharmacopoeia commisson, 1102m, London 1963). The test results show that the components have a strong and satisfactory effect.

  DOI：

  10.1080/10426500701242848