3-((4-fluorophenyl)diazenyl)-4-hydroxy-8-methylquinolin-2(1H)-one | 1436460-85-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-((4-fluorophenyl)diazenyl)-4-hydroxy-8-methylquinolin-2(1H)-one
• CAS: 1436460-85-3
• 化学式: C₁₆H₁₂FN₃O₂
• 分子量: 297.289
• InChiKey: CXRZESNEFHMBHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  22.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  77.81
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  N1,N3-二(2-甲基苯基)-丙烷二酰胺 在 甲烷磺酸 、 四磷十氧化物 、 sodium hydroxide 作用下， 以 水 为溶剂， 反应 3.5h， 生成 3-((4-fluorophenyl)diazenyl)-4-hydroxy-8-methylquinolin-2(1H)-one
  参考文献：
  名称：

  Novel azo dyes derived from 8-methyl-4-hydroxyl-2-quinolone: Synthesis, UV–vis studies and biological activity

  摘要：

  In this study, N,N'-di-(2-methylphenyl)malonamide was synthesized and reacted with polyphosphoric acid to afford 8-methyl-4-hydroxyl-2-quinolone. Eight novel azo disperse dyes were then synthesized by linking diazotized p-substituted aniline derivatives with 8-methyl-4-hydroxyl-2-quinolone. The solvatochromism of these azo dyes in various solvents was evaluated. All the compounds were then evaluated for their antibacterial activity against four bacteria, namely, Bacillus subtilis, Micrococcus luteus, Salmonella enterica, and Pseudomonas aeruginosa. The results showed that some of these compounds have high levels of antibacterial activity. (C) 2013 E.O. Moradi Rufchahi. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.03.002