1,2-bis((3-((1H-benzo[d]imidazol-1-yl)methyl)quinolin-2-yl)oxy)benzene | 1174740-96-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1,2-bis((3-((1H-benzo[d]imidazol-1-yl)methyl)quinolin-2-yl)oxy)benzene
• CAS: 1174740-96-5
• 化学式: C₄₀H₂₈N₆O₂
• 分子量: 624.701
• InChiKey: LBYMHIVYSQKHMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.16
• 重原子数：
  48.0
• 可旋转键数：
  8.0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  79.88
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  2,6-双(溴甲基)吡啶 、 1,2-bis((3-((1H-benzo[d]imidazol-1-yl)methyl)quinolin-2-yl)oxy)benzene 以 乙腈 为溶剂， 反应 120.0h， 以65%的产率得到
  参考文献：
  名称：

  Synthesis and antibacterial activity of some novel imidazole-based dicationic quinolinophanes

  摘要：

  Synthesis of novel quinoline based dicationic benzimidazolophanes and imidazolophanes incorporating various spacer units is described. Some of the quinolinophanes 1b, 3a, 3b and 4a exhibit good antibacterial activity against most of the human pathogenic bacteria in the tested concentrations as compared to the other cyclophanes as well as the test control, streptomycin. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.05.019
• 作为产物：
  描述：

  苯并咪唑 、 在 sodium hydroxide 作用下， 以 水 、 乙腈 为溶剂， 反应 48.0h， 以72%的产率得到1,2-bis((3-((1H-benzo[d]imidazol-1-yl)methyl)quinolin-2-yl)oxy)benzene
  参考文献：
  名称：

  Synthesis and antibacterial activity of some novel imidazole-based dicationic quinolinophanes

  摘要：

  Synthesis of novel quinoline based dicationic benzimidazolophanes and imidazolophanes incorporating various spacer units is described. Some of the quinolinophanes 1b, 3a, 3b and 4a exhibit good antibacterial activity against most of the human pathogenic bacteria in the tested concentrations as compared to the other cyclophanes as well as the test control, streptomycin. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.05.019