(5R,8R)-6-propyl-8β-hydroxymethyl-9α-hydroxyergoline | 210821-12-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (5R,8R)-6-propyl-8β-hydroxymethyl-9α-hydroxyergoline
• CAS: 210821-12-8
• 化学式: C₁₈H₂₄N₂O₂
• 分子量: 300.401
• InChiKey: YKGPFOPVENVHEF-DGCUDZEOSA-N

物化性质

• 沸点：
  533.0±50.0 °C(Predicted)
• 密度：
  1.232±0.06 g/cm3(Predicted)

反应信息

• 作为反应物：
  描述：

  (5R,8R)-6-propyl-8β-hydroxymethyl-9α-hydroxyergoline 在 sodium hydroxide 、 sodium tetrahydroborate 、 吡啶盐酸盐 、 三氯氧磷 作用下， 以 吡啶 、 甲醇 、 二甲基亚砜 为溶剂， 生成 (7R,9aR)-7-Methyl-9-propyl-2,7,8,9,9a,10-hexahydro-pyrrolo[3',2':5,6]cyclohepta[1,2,3-cd]indole
  参考文献：
  名称：

  5(10→9)Abeo-ergoline derivatives: Synthesis, 5-HT1A-receptor affinity and selectivity

  摘要：

  The synthesis and the structure-affinity relationship (S.A.F.I.R.) study for the 5-HT1A receptor sites of a novel series of 5(10-->9)abeo-ergoline derivatives are presented. Most derivatives showed moderate to high affinity and selectivity for 5-HT1A receptor sites. The structure-affinity relationship pointed out the role of the substituent at position 8, and the outstanding importance of the reduction of the indole 2,3-double bond for achieving the highest 5-HT1A affinity and selectivity within the compounds presented. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(98)80062-7
• 作为产物：
  描述：

  (6aR,9R)-7-Propyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid methyl ester 生成 (5R,8R)-6-propyl-8β-hydroxymethyl-9α-hydroxyergoline
  参考文献：
  名称：

  5(10→9)Abeo-ergoline derivatives: Synthesis, 5-HT1A-receptor affinity and selectivity

  摘要：

  The synthesis and the structure-affinity relationship (S.A.F.I.R.) study for the 5-HT1A receptor sites of a novel series of 5(10-->9)abeo-ergoline derivatives are presented. Most derivatives showed moderate to high affinity and selectivity for 5-HT1A receptor sites. The structure-affinity relationship pointed out the role of the substituent at position 8, and the outstanding importance of the reduction of the indole 2,3-double bond for achieving the highest 5-HT1A affinity and selectivity within the compounds presented. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(98)80062-7