1-<6-(2-methyl<1,3>dioxolan-2-yl)-pyridin-2-yl>-ethanone | 170449-83-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-<6-(2-methyl<1,3>dioxolan-2-yl)-pyridin-2-yl>-ethanone
• 英文别名: 6-(2-methyl-1,3-dioxolane-2-yl)-2-diacetylpyridine；1-[6-(2-Methyl-1,3-dioxolan-2-yl)pyridin-2-yl]ethanone
• CAS: 170449-83-9
• 化学式: C₁₁H₁₃NO₃
• 分子量: 207.229
• InChiKey: FKZHLQKDPJQARM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  48.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-<6-(2-methyl<1,3>dioxolan-2-yl)-pyridin-2-yl>-ethanone 在 盐酸 、 sodium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 4.5h， 生成 4-(6-acetyl-pyridin-2-yl)-4-oxobutyric acid
  参考文献：
  名称：

  Artificial Metalloesterases Constructed by Site-Directed Attachment of Oximinato Metal Centers to Poly(ethylenimine) Containing β-Cyclodextrin

  摘要：

  In an effort to establish a methodology for construction of active sites of artificial enzymes, site-directed attachment of 2,6-diacetylpyridineketoxime (III) to poly(ethylenimine) (PEI) containing beta-cyclodextrin (CD) was attempted. The site-directed functionalization exploited a t-butylphenyl ester (1) of a carboxylic acid containing a precursor of III. Anchoring of the t-butylphenyl group of I by the CD portion followed by transfer of III moiety to an amino group located in the vicinity of the CD moiety would lead to introduction of III in proximity to the CD moiety. By acylation in DMSO of CD-PEI with the phenyl ester (II), instead of the t-butylphenyl ester, III was introduced randomly to CD-PEI. In the presence of the Ni(II) or Zn(II) complex of the III-containing CD-PEI prepared by either the site-directed or the random functionalization method, ester hydrolysis of 4-(4'-acetoxy-phenylazo)benzenesulfonate (TV) was considerably enhanced. Analysis of the kinetic data measured at various pHs revealed that k(cat) for the PEI derivative prepared by site-directed modification was three to six times greater than that by random modification. The results were taken to indicate that I transferred III to the vicinity of the CD moiety of CD-PEI, but that orientation of III and the CD cavity in the resulting PEI derivative was not very productive for deacylation of IV complexed by the CD cavity. (C) 1998 Academic Press

  DOI：

  10.1006/bioo.1998.1090
• 作为产物：
  描述：

  2,6-二乙酰基吡啶 、 乙二醇 在 p-toluylsulfonic acid 作用下， 以30%的产率得到1-<6-(2-methyl<1,3>dioxolan-2-yl)-pyridin-2-yl>-ethanone
  参考文献：
  名称：

  带有束缚电位核糖核酸的AZT磷酸二酯和三酯衍生物的合成及性能

  摘要：

  描述了用束缚的N，N，N'三甲基乙二胺，N-甲基哌嗪和2，6-二乙酰基吡啶作为具有潜在核糖核酸酶活性的AZT的前药合成AZT的磷酸酯衍生物。这些化合物的金属络合物应结合逆转录酶抑制作用和水解HIV RNA的能力。已经使用了不同的磷化学方法来合成磷酸二酯。磷酸三酯的合成是通过在一个或两个化学步骤中通过活化的磷酸二酯对卤代基团进行亲核取代而实现的。N，N，N'-三甲基乙二胺衍生物的铜配合物被充分表征，并通过毛细管电泳证明了其对25-mer和28-mer寡核糖核苷酸的核糖核酸酶活性。在体外 抗HIV初步检测显示，螯合铜对前药活性无协同作用。

  DOI：

  10.1016/0040-4020(95)00320-8

文献信息

• Structural tuning of ancillary chelate in tri-carboxyterpyridine Ru(<scp>ii</scp>) sensitizers for dye sensitized solar cells
  作者：Chun-Cheng Chou、Pei-Hua Chen、Fa-Chun Hu、Yun Chi、Shu-Te Ho、Ji-Jung Kai、Shih-Hung Liu、Pi-Tai Chou

  DOI：10.1039/c3ta14876a

  日期：——

  Systematically changing the ancillary chelate from L3 to L6, together with addition of a 3,4-ethylenedioxythiophene (EDOT) appendage, boosts the overall efficiencies of a fabricated DSC device.

  系统地将辅助螯合物从L3更改为L6，并添加一个3,4-乙烯二氧基噻吩（EDOT）基团，可以提高制造的DSC器件的总体效率。