4-Chlorobenzoic acid (4-quinolinylmethylene)hydrazide | 106869-30-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-Chlorobenzoic acid (4-quinolinylmethylene)hydrazide
• 英文别名: 4-chloro-N-(quinolin-4-ylmethylideneamino)benzamide
• CAS: 106869-30-1
• 化学式: C₁₇H₁₂ClN₃O
• 分子量: 309.755
• InChiKey: LUUZIOZAJKIBTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-喹啉甲醛 、 4-氯苯甲酰肼 在 甲酸 作用下， 以 二甲基亚砜 为溶剂， 生成 4-Chlorobenzoic acid (4-quinolinylmethylene)hydrazide
  参考文献：
  名称：

  Mechanistic differences between in vitro assays for hydrazone-based small molecule inhibitors of anthrax lethal factor

  摘要：

  A systematically generated series of hydrazones were analyzed as potential inhibitors of anthrax lethal factor. The hydrazones were screened using one UV-based and two fluorescence-based in vitro assays. The study identified several inhibitors with IC50 values in the micromolar range, and importantly, significant differences in the types of inhibition were observed with the different assays. (c) 2006 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bioorg.2006.07.004

文献信息

• Anthelmintic quinolinyl acylhydrazones, method of use and compositions
  申请人：The Upjohn Company

  公开号：US04870082A1

  公开（公告）日：1989-09-26

  This invention concerns a process for killing internal parasites, especially nematodes and cestodes affecting warm blooded animals such as sheep, cattle, swine, goats, dogs, cats, horses and humans as well as poultry by administering an effective amount of a compound of the Formula I: ##STR1## Certain of the compounds of Formula I are novel and in further embodiments of the invention provide novel compounds and compositions for use in the process of the invention. The compounds are readily prepared by conventional chemical reactions.

  本发明涉及一种用于杀死内寄生虫的过程，特别是影响温血动物（例如绵羊、牛、猪、山羊、狗、猫、马和人类）以及家禽的线虫和绦虫，通过给予化合物I的有效量进行。公式I的某些化合物是新颖的，在本发明的进一步实施中提供了用于本发明过程的新颖化合物和组合物。这些化合物可以通过常规化学反应轻松制备。