2-(Furan-2-yl)-1-(2-methoxyquinolin-3-yl)-4-(methylamino)-1-phenylbutan-2-ol | 916800-59-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(Furan-2-yl)-1-(2-methoxyquinolin-3-yl)-4-(methylamino)-1-phenylbutan-2-ol
• CAS: 916800-59-4
• 化学式: C₂₅H₂₆N₂O₃
• 分子量: 402.493
• InChiKey: QINXURUNQALEIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  67.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-[Benzyl(methyl)amino]-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(furan-2-yl)-1-phenylbutan-2-ol 在 palladium 10% on activated carbon 甲酸铵 作用下， 以 甲醇 为溶剂， 反应 1.0h， 生成 2-(Furan-2-yl)-1-(2-methoxyquinolin-3-yl)-4-(methylamino)-1-phenylbutan-2-ol
  参考文献：
  名称：

  [EN] QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS
  [FR] DERIVES DE QUINOLEINE UTILISES COMME AGENTS ANTIBACTERIENS

  摘要：

  公开号：

  WO2007014934A3

文献信息

• QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS
  申请人：Janssen Pharmaceutica NV

  公开号：EP1912649B1

  公开（公告）日：2012-10-10
• Quinoline Derivatives as Antibacterial Agents
  申请人：Andries Koenraad Jozef Lodewijk Marcel

  公开号：US20080227775A1

  公开（公告）日：2008-09-18

  Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of Formula (Ia) or (Ib) a pharmaceutically acceptable acid or base addition salt thereof, a quaternary amine thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof, wherein R 1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1, 2, 3 or 4; R 2 is hydrogen, hydroxy, thio, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula R 3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; R 4 is hydrogen, alkyl or benzyl; R 5 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; or two vicinal R 5 radicals may be taken together to form together with the phenyl ring to which they are attached a naphthyl; r is 1, 2, 3, 4 or 5; R 6 is hydrogen, alkyl, Ar or Het; R 7 is hydrogen or alkyl; R 5 is oxo; or R 7 and R 5 together form the radical —CH═CH—N═; Z is CH 2 or C(═O).
• US8691800B2
  申请人：——

  公开号：US8691800B2

  公开（公告）日：2014-04-08