benzyl β-D-galactopyranosyl-(1->3)-β-D-galactopyranosyl-(1->4)-β-D-glucopyranoside | 18404-78-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: benzyl β-D-galactopyranosyl-(1->3)-β-D-galactopyranosyl-(1->4)-β-D-glucopyranoside
• CAS: 18404-78-9
• 化学式: C₂₅H₃₈O₁₆
• 分子量: 594.567
• InChiKey: DBDMBUCEVVLURG-PJSWDQKWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.35
• 重原子数：
  41.0
• 可旋转键数：
  10.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  257.68
• 氢给体数：
  10.0
• 氢受体数：
  16.0

反应信息

• 作为反应物：
  描述：

  benzyl β-D-galactopyranosyl-(1->3)-β-D-galactopyranosyl-(1->4)-β-D-glucopyranoside 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以98%的产率得到3'-galactosyl-lactose
  参考文献：
  名称：

  Identification and synthesis of a trisaccharide produced from lactose by transgalactosylation

  摘要：

  Enzymatic transgalactosylation of lactose by means of Streptococcus thermophilus, subspecies DN-001065, led to a mixture of D-galactose (similar to 4%), D-glucose ( similar to 15%), lactose (similar to 51%), minor disaccharides (6%), trisaccharides ( similar to 20%) and tetrasaccharides (3%). The major trisaccharide ( similar to 16%) was identified by NMR spectroscopy and chemical synthesis as bring the known beta-D-galactopyranosyl-(1-->3)-beta-D-galactopyranosyl-(1-->4)-D-glucose (3'-beta-D-galactopyranosyl-lactose). It was purified from a mixture of peracetylated oligosaccharides by column chromatography followed by deacetylation. For the first time, 3'-beta-D-galactopyranosyl-lactose has been obtained on the 1 g scale, by resorting to simple techniques and equipment. NMR spectra have been unambiguously assigned. (C) 3000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0008-6215(99)00309-2
• 作为产物：
  描述：

  benzyl O-(2,6-di-O-acetyl-β-D-galactopyranosyl)-(1<*>4)-2,3,6-tri-O-acetyl-β-D-glucopyranoside 在 吡啶 、 甲醇 、 三氟甲磺酸三甲基硅酯 、 sodium methylate 作用下， 以 二氯甲烷 为溶剂， 反应 53.0h， 生成 benzyl β-D-galactopyranosyl-(1->3)-β-D-galactopyranosyl-(1->4)-β-D-glucopyranoside
  参考文献：
  名称：

  Identification and synthesis of a trisaccharide produced from lactose by transgalactosylation

  摘要：

  Enzymatic transgalactosylation of lactose by means of Streptococcus thermophilus, subspecies DN-001065, led to a mixture of D-galactose (similar to 4%), D-glucose ( similar to 15%), lactose (similar to 51%), minor disaccharides (6%), trisaccharides ( similar to 20%) and tetrasaccharides (3%). The major trisaccharide ( similar to 16%) was identified by NMR spectroscopy and chemical synthesis as bring the known beta-D-galactopyranosyl-(1-->3)-beta-D-galactopyranosyl-(1-->4)-D-glucose (3'-beta-D-galactopyranosyl-lactose). It was purified from a mixture of peracetylated oligosaccharides by column chromatography followed by deacetylation. For the first time, 3'-beta-D-galactopyranosyl-lactose has been obtained on the 1 g scale, by resorting to simple techniques and equipment. NMR spectra have been unambiguously assigned. (C) 3000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0008-6215(99)00309-2