(2S)-2-[(1R)-3-(2-chlorophenyl)-3-oxo-1-phenylpropyl]cyclohexan-1-one | 1523569-92-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (2S)-2-[(1R)-3-(2-chlorophenyl)-3-oxo-1-phenylpropyl]cyclohexan-1-one
• CAS: 1523569-92-7
• 化学式: C₂₁H₂₁ClO₂
• 分子量: 340.85
• InChiKey: CTCXBBHJPSEMLS-WMZOPIPTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  环己酮 、 1-(2-chlorophenyl)-3-phenylprop-2-en-1-one 在 (S)-2-((1-(pyrrolidin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)isoindoline-1,3-dione 、 苯甲酸 作用下， 以 neat (no solvent) 为溶剂， 反应 72.0h， 以85%的产率得到
  参考文献：
  名称：

  Direct asymmetric Michael addition of ketones to chalcones catalyzed by a hydroxyphthalimide derived triazole–pyrrolidine

  摘要：

  An efficient protocol for the enantioselective Michael additions of ketones to chalcones catalyzed by a hydroxyphthalimide linked triazole-pyrrolidine derivative has been developed. The corresponding products, 1,5-dicarbonyl compounds, were obtained in good yields with high levels of stereoselectivities under mild reaction conditions employing benzoic acid as an additive. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2013.11.002

文献信息

• Direct asymmetric Michael addition of ketones to chalcones catalyzed by a hydroxyphthalimide derived triazole–pyrrolidine
  作者：Togapur Pavan Kumar、Mohammad Abdul Sattar、Vanka Uma Maheshwara Sarma

  DOI：10.1016/j.tetasy.2013.11.002

  日期：2013.12

  An efficient protocol for the enantioselective Michael additions of ketones to chalcones catalyzed by a hydroxyphthalimide linked triazole-pyrrolidine derivative has been developed. The corresponding products, 1,5-dicarbonyl compounds, were obtained in good yields with high levels of stereoselectivities under mild reaction conditions employing benzoic acid as an additive. (C) 2013 Elsevier Ltd. All rights reserved.