2-[7-[1-[tert-butyl(dimethyl)silyl]oxypropyl]-9-oxo-11H-indolizino[1,2-b]quinolin-8-yl]acetonitrile | 1260237-42-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-[7-[1-[tert-butyl(dimethyl)silyl]oxypropyl]-9-oxo-11H-indolizino[1,2-b]quinolin-8-yl]acetonitrile
• CAS: 1260237-42-0
• 化学式: C₂₆H₃₁N₃O₂Si
• 分子量: 445.637
• InChiKey: QWFWIXJWHBYAAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.96
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  66.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[7-[1-[tert-butyl(dimethyl)silyl]oxypropyl]-9-oxo-11H-indolizino[1,2-b]quinolin-8-yl]acetonitrile 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 1.5h， 以29%的产率得到19-Ethyl-18-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,17-dione
  参考文献：
  名称：

  Synthesis of new cytotoxic E-ring modified camptothecins

  摘要：

  In an effort to decrease the toxicity and improve the stability of the E-ring of camptothecin, new analogues with an 'inverted' lactone ring were designed and synthesized. The compounds retained a good cytotoxic activity on human non-small lung cancer cells H-460. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.130
• 作为产物：
  描述：

  sodium cyanide 、 以 二甲基亚砜 为溶剂， 反应 2.0h， 以54%的产率得到2-[7-[1-[tert-butyl(dimethyl)silyl]oxypropyl]-9-oxo-11H-indolizino[1,2-b]quinolin-8-yl]acetonitrile
  参考文献：
  名称：

  Synthesis of new cytotoxic E-ring modified camptothecins

  摘要：

  In an effort to decrease the toxicity and improve the stability of the E-ring of camptothecin, new analogues with an 'inverted' lactone ring were designed and synthesized. The compounds retained a good cytotoxic activity on human non-small lung cancer cells H-460. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.130

文献信息

• Synthesis of new cytotoxic E-ring modified camptothecins
  作者：Salvatore Cananzi、Sabrina Dallavalle、Alberto Bargiotti、Lucio Merlini、Roberto Artali、Giovanni Luca Beretta

  DOI：10.1016/j.tetlet.2010.09.130

  日期：2010.12

  In an effort to decrease the toxicity and improve the stability of the E-ring of camptothecin, new analogues with an 'inverted' lactone ring were designed and synthesized. The compounds retained a good cytotoxic activity on human non-small lung cancer cells H-460. (C) 2010 Elsevier Ltd. All rights reserved.