2,2-Dimethyl-4-(2,2,2-trifluoroethoxymethyl)-1,3-dioxolane | 198714-10-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2-Dimethyl-4-(2,2,2-trifluoroethoxymethyl)-1,3-dioxolane
• CAS: 198714-10-2
• 化学式: C₈H₁₃F₃O₃
• 分子量: 214.185
• InChiKey: MTEQHTUFTPNHRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,2-Dimethyl-4-(2,2,2-trifluoroethoxymethyl)-1,3-dioxolane 在 吡啶 、 盐酸 、 diphenyl picryl hydrazyl 作用下， 以 甲醇 、 乙醚 为溶剂， 反应 4.0h， 生成 2-Methyl-acrylic acid 1-(2-methyl-acryloyloxymethyl)-2-(2,2,2-trifluoro-ethoxy)-ethyl ester
  参考文献：
  名称：

  Fluoroalkyl derivatives of protected glycerol by nucleophilic substitution. Fluorine-containing amphiphilic mono- and bis-methacrylates

  摘要：

  The tosylate of protected glycerol (solketal, 4-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolane) was fluoroalkylated by a nucleophilic substitution reaction with sodium polyfluoroalkoxides. On deprotection, 3-O-fluoroalkylated glycerol was obtained which was converted to mono-and bis-methacrylates; analogous methacrylate derivatives were prepared from 3,3,4,5,5,5-hexafluoro-pentane-1,2-diol. (C) 1997 Elsevier Science S.A.

  DOI：

  10.1016/s0022-1139(97)00063-8
• 作为产物：
  描述：

  2,2,2-三氟乙醇 、 2,2-二甲基-1,3-二氧环戊基-4-甲醇对甲基苯磺酸酯 在 sodium 作用下， 以31.3%的产率得到2,2-Dimethyl-4-(2,2,2-trifluoroethoxymethyl)-1,3-dioxolane
  参考文献：
  名称：

  Fluoroalkyl derivatives of protected glycerol by nucleophilic substitution. Fluorine-containing amphiphilic mono- and bis-methacrylates

  摘要：

  The tosylate of protected glycerol (solketal, 4-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolane) was fluoroalkylated by a nucleophilic substitution reaction with sodium polyfluoroalkoxides. On deprotection, 3-O-fluoroalkylated glycerol was obtained which was converted to mono-and bis-methacrylates; analogous methacrylate derivatives were prepared from 3,3,4,5,5,5-hexafluoro-pentane-1,2-diol. (C) 1997 Elsevier Science S.A.

  DOI：

  10.1016/s0022-1139(97)00063-8