(E)-1-(4-bromophenyl)-4-phenyl-3-butene-1,2-dione | 1602935-27-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-1-(4-bromophenyl)-4-phenyl-3-butene-1,2-dione
• 英文别名: (E)-1-(4-bromophenyl)-4-phenylbut-3-ene-1,2-dione
• CAS: 1602935-27-2
• 化学式: C₁₆H₁₁BrO₂
• 分子量: 315.166
• InChiKey: DLLFXBXPOCNAGS-IZZDOVSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二乙二醛对溴苯 、 苯乙炔 在 吗啉 、 copper(I) bromide 作用下， 以 1,4-二氧六环 为溶剂， 以29%的产率得到(E)-1-(4-bromophenyl)-4-phenyl-3-butene-1,2-dione
  参考文献：
  名称：

  CuBr-Promoted Formal Hydroacylation of 1-Alkynes with Glyoxal Derivatives: An Unexpected Synthesis of 1,2-Dicarbonyl-3-enes

  摘要：

  An efficient and concise protocol has been developed for the highly regio- and stereoselective synthesis of E-1,2-dicarbonyl-3-ene derivatives by a copper-promoted reaction of 1-alkynes with a-carbonyl aldehydes in the presence of morpholine. The products obtained are believed as the formal hydroacylation of the triple bond.

  DOI：

  10.1021/jo500199v

文献信息

• CuBr-Promoted Formal Hydroacylation of 1-Alkynes with Glyoxal Derivatives: An Unexpected Synthesis of 1,2-Dicarbonyl-3-enes
  作者：Shufeng Chen、Xiaojie Li、Haiying Zhao、Baoguo Li

  DOI：10.1021/jo500199v

  日期：2014.5.2

  An efficient and concise protocol has been developed for the highly regio- and stereoselective synthesis of E-1,2-dicarbonyl-3-ene derivatives by a copper-promoted reaction of 1-alkynes with a-carbonyl aldehydes in the presence of morpholine. The products obtained are believed as the formal hydroacylation of the triple bond.