(2R,3R,4S,5S)-2-{6-(2-Cyclohexyl-ethylamino)-2-[2-(1-methyl-1H-imidazol-4-yl)-ethylamino]-purin-9-yl}-5-(3-ethyl-isoxazol-5-yl)-tetrahydro-furan-3,4-diol | 235744-27-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3R,4S,5S)-2-{6-(2-Cyclohexyl-ethylamino)-2-[2-(1-methyl-1H-imidazol-4-yl)-ethylamino]-purin-9-yl}-5-(3-ethyl-isoxazol-5-yl)-tetrahydro-furan-3,4-diol
• 英文别名: (2R,3R,4S,5S)-2-[6-(2-cyclohexylethylamino)-2-[2-(1-methylimidazol-4-yl)ethylamino]purin-9-yl]-5-(3-ethyl-1,2-oxazol-5-yl)oxolane-3,4-diol
• CAS: 235744-27-1
• 化学式: C₂₈H₃₉N₉O₄
• 分子量: 565.676
• InChiKey: BYZVGFPGQNGQMM-ZOJNDGCKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  41
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  161
• 氢给体数：
  4
• 氢受体数：
  11

文献信息

• 2-(PURIN-9-yl)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES
  申请人：GLAXO GROUP LIMITED

  公开号：EP1051425B1

  公开（公告）日：2002-10-30
• US6762170B1
  申请人：——

  公开号：US6762170B1

  公开（公告）日：2004-07-13
• [EN] 2-(PURIN-9-yl)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES<br/>[FR] DERIVES DE 2-(PURINE-9-YL)-TETRAHYDROFURANE-3,4-DIOL
  申请人：——

  公开号：WO1999038877A2

  公开（公告）日：1999-08-05

  [EN] There are provided according to the invention, novel compounds of formula (I) wherein R<1>, R<2> and R<3> are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
  [FR] L'invention concerne de nouveaux composés, représentés par la formule (I): dans laquelle R<1>, R<2> et R<3> sont tels que définis dans la description. L'invention concerne également des procédés permettant de préparer ces composés, des formulations les renfermant et leur utilisation pour le traitement thérapeutique des maladies inflammatoires.
• [EN] DIHYDROISOXAZOLYL SUBSTITUTED TETRAHYDROFURAN COOMPOUNDS AS INTERMEDIATES IN THE PREPARATION OF 2-(PURIN-9-YL) - TETRAHYDROFURAN DERIVATIVES<br/>[FR] COMPOSES DE TETRAHYDROFURAN DE DIHYDROISOXAZOLYLE SUBSTITUES UTILISES EN TANT QU'INTERMEDIAIRE DANS LA PREPARATION DE DERIVES DE 2-(PURINE-9-YL) - TETRAHYDROFURAN
  申请人：GLAXO GROUP LTD

  公开号：WO2003080604A1

  公开（公告）日：2003-10-02

  Dihydroisoxazolyl substituted Tetrahydrofuran compounds as intermediates in the preparation of 2 (puxin-9-y1)-tetrahydrofuran derivatives A process for preparing a compound of formula (I) which comprises dehydration of a compound of formula (II) according to Step (i): wherein R1 represents methyl, ethyl, -CH=CP2, n-propyl, -CH2FH=CH2, -CH=CHCH3, isopropyl, isopropenyl, cyclopropyl, cyclopropenyl, cyclôpropylmethyl, cyclopropenylmethyl, -CH (OH) CH3, - (CH2) q halogen, - (CH 2) hY (CH2) iH, - (CH2) kZ, - (CH2)hCO(CH2)oH, - (CH2)rS (O) t (CH2) sH or - (CH 2 )kC( (CH2)uH)=NO(CH2)vH; wherein Y represents O, S or NH (CH2)j; Z represents -COO(CH2)1H or -CON (CH2)mH((CH2)nH); q represents an intégér 0 to 3; h represents an integer 0 to 2; i represents an integer 0 to 2 such that h+i is in the range 0 to 3; j represents an integer 0 to 2 such that h+i+j is in the range 0 to 3; k represents 0 or 1; 1 represents 1 or 2, such that k+ 1 is in the range 1 to 2; m and n independently represent an integer 0 to 2 such that k+m+n is in the range 0 to 2; o represents an integer 0 to 2 such that h+o is in the range 0 to 2; r and s independently represent 1 or 2 such that r+s is in the range 2 to 3; t represents 1 or 2; u and v independently represent 0 or 1 such that k+u+v is in the range O to 1; L1 and L2 represent hydroxy or a protected derivative' thereof; and L3 represent a leaving group.
• [EN] PROCESS FOR THE PREPARATION OF INTERMEDIATES IN THE SYNTHESIS OF 2- (PURIN-9-YL) - TETRAHYDROFURAN-3,4-DIOL DERIVATIVES<br/>[FR] PROCEDES POUR LA PREPARATION D'INTERMEDIAIRES DANS LA SYNTHESE DE DERIVES DE 2-(PURINE-9-YL)-TERTRAHYDROFURAN-3,4-DIOL
  申请人：GLAXO GROUP LTD

  公开号：WO2003080613A1

  公开（公告）日：2003-10-02

  A process for preparing a compound of formula (II) Which comprises reacting a compound of formula (IV) wherein P1 represents a protecting group which is a cyclic ether connected to the purine ring nitrogen in the 2-position, or a salt thereof, with a compound of formula (V) R2NH2 (V) followed by deprotection and optional salt conversion to yield the compound of formula (II) or a salt thereof.