epicoccin O | 1235384-16-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: epicoccin O
• 英文别名: (1R,4S,5S,9R,11R,14S,15S,17S,19R)-5,15-dihydroxy-11-methylsulfanyl-21-thia-3,13-diazahexacyclo[15.3.1.01,13.03,11.04,9.014,19]henicosane-2,8,12,18-tetrone
• CAS: 1235384-16-3
• 化学式: C₁₉H₂₂N₂O₆S₂
• 分子量: 438.525
• InChiKey: MIGDXSIYPPSPQT-VSVMUBLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  29
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  166
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  epicoccin O 、 甲氧基-三氟甲基苯 在 吡啶 作用下， 以0.2 mg的产率得到[(1R,4S,5S,9R,11R,14S,15S,17S,19R)-11-methylsulfanyl-2,8,12,18-tetraoxo-15-[(2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl]oxy-21-thia-3,13-diazahexacyclo[15.3.1.01,13.03,11.04,9.014,19]henicosan-5-yl] (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
  参考文献：
  名称：

  Thiodiketopiperazines Produced by the Endophytic Fungus Epicoccum nigrum

  摘要：

  Thirteen new thiodiketopiperazines, epicoccin I (1), ent-epicoccin G (2), and epicoccins J-T (3-13), together with six known diketopiperazines (14-19), have been isolated from the endophytic fungus Epicoccum nigram. The structures of 1, 2, and 10 were confirmed by X-ray crystallography, and the absolute configurations of 2, 4, 6, and 8 were assigned using Moshers' method. Compounds 2, 6, 12, and 17 showed potent activities in vitro against the release of beta-glucuronidase in rat polymorphonuclear leukocytes induced by platelet-activating factor, with IC50 values of 3.07, 4.16, 4.95, and 1.98 mu M, respectively. None of the 19 compounds exhibited detectable cytotoxic activities toward six tumor cell lines (A549, Bc-17402, BGC-823, HCT-116, and A2780) in the MTT assay.

  DOI：

  10.1021/np1000895