S-[2-(2-hydroxyphenyl)-2-oxoethyl] ethanethioate | 1121543-15-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: S-[2-(2-hydroxyphenyl)-2-oxoethyl] ethanethioate
• CAS: 1121543-15-4
• 化学式: C₁₀H₁₀O₃S
• 分子量: 210.254
• InChiKey: UYMRLYUEPFYWHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  79.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  Α,Α-二溴邻羟基苯乙酮 、 alkaline earth salt of/the/ methylsulfuric acid 以 水 、 丙酮 为溶剂， 反应 1.0h， 以29%的产率得到
  参考文献：
  名称：

  Reactions of ortho-substituted α,α-dibromoacetophenones with nucleophiles: first examples of combined carbophilic and bromophilic attack on C–Br bonds

  摘要：

  An efficient method for the formation of alpha-carbonyl-monosubstituted acetophenones from ortho-methoxy-and ortho-hydroxy-alpha,alpha-dibromoacetopheiiones and a range of selected nucleophiles, occurring via a carbophilic substitution/bromophilic substitution/protonation cascade process, is described. In turn, the preparation of alpha,alpha-dibromoacetophenones, isolated in high yields, relies on the neighboring group participation of the ortho-substituents in the starting ortho-substituted acetophenones. (C) 2008 Elsevier Ltd. All rights reserved

  DOI：

  10.1016/j.tetlet.2008.11.104

文献信息

• Reactions of ortho-substituted α,α-dibromoacetophenones with nucleophiles: first examples of combined carbophilic and bromophilic attack on C–Br bonds
  作者：Jovana Tatar、Marija Baranac-Stojanović、Milovan Stojanović、Rade Marković

  DOI：10.1016/j.tetlet.2008.11.104

  日期：2009.2

  An efficient method for the formation of alpha-carbonyl-monosubstituted acetophenones from ortho-methoxy-and ortho-hydroxy-alpha,alpha-dibromoacetopheiiones and a range of selected nucleophiles, occurring via a carbophilic substitution/bromophilic substitution/protonation cascade process, is described. In turn, the preparation of alpha,alpha-dibromoacetophenones, isolated in high yields, relies on the neighboring group participation of the ortho-substituents in the starting ortho-substituted acetophenones. (C) 2008 Elsevier Ltd. All rights reserved