3-methyl-8-methoxyphenanthridin-6(5H)-one | 1417642-90-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-methyl-8-methoxyphenanthridin-6(5H)-one
• 英文别名: 8-methoxy-3-methyl-5H-phenanthridin-6-one
• CAS: 1417642-90-0
• 化学式: C₁₅H₁₃NO₂
• 分子量: 239.274
• InChiKey: LTBOQXILDUZRQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-methoxy-4'-methylbiphenyl-2-carboxamide 在 copper(l) iodide 、 potassium tert-butylate 、 氧气 、 三苯基膦 作用下， 以 邻二甲苯 为溶剂， 反应 18.0h， 以85%的产率得到3-methyl-8-methoxyphenanthridin-6(5H)-one
  参考文献：
  名称：

  Synthesis of Phenanthridin-6(5H)-ones via Copper-Catalyzed Cyclization of 2-Phenylbenzamides

  摘要：

  Synthesis of phenanthridin-6(5H)-ones was achieved via copper-catalyzed cyclization of 2-phenylbenzamides using air as the oxidant and KOt-Bu as the base. It was discovered that, besides Ph3P, other ligands such as 1,10-phenanthroline, TMEDA as well as L-proline could also be used as the ligand to effect the transformation.

  DOI：

  10.1055/s-0032-1316898

文献信息

• Synthesis of Phenanthridin-6(5H)-ones via Copper-Catalyzed Cyclization of 2-Phenylbenzamides
  作者：Ze Tan、Wei Yu、Qingwen Gui、Zhiyong Yang、Xiang Chen、Jidan Liu、Ruqing Guo

  DOI：10.1055/s-0032-1316898

  日期：——

  Synthesis of phenanthridin-6(5H)-ones was achieved via copper-catalyzed cyclization of 2-phenylbenzamides using air as the oxidant and KOt-Bu as the base. It was discovered that, besides Ph3P, other ligands such as 1,10-phenanthroline, TMEDA as well as L-proline could also be used as the ligand to effect the transformation.