bis-MPA-OH dendrimer | 685901-24-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: bis-MPA-OH dendrimer
• 英文别名: [3-[2,2-bis[[3-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxy-2-[[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxymethyl]-2-methylpropanoyl]oxymethyl]butoxy]-2-[[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxymethyl]-2-methyl-3-oxopropyl] 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate
• CAS: 685901-24-0
• 化学式: C₅₁H₈₆O₃₀
• 分子量: 1179.23
• InChiKey: JPMXKQHBVULZDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5
• 重原子数：
  81
• 可旋转键数：
  49
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  480
• 氢给体数：
  12
• 氢受体数：
  30

反应信息

• 作为反应物：
  描述：

  bis-MPA-OH dendrimer 、 3-巯基丙酸 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 生成
  参考文献：
  名称：

  내충격성이 우수한 광학 재료용 에스터 티올 화합물

  摘要：

  本发明涉及用于优良的光学材料的酯基噻唑化合物，根据本发明的酯基噻唑化合物包含多个酯键和噻唑官能团，因此从中获得的聚蒂氧烷表现出高折射率，高冲击性，高耐热性等优异的光学和机械特性，因此可用于制造各种塑料光学镜片，如眼镜镜片，相机镜头等。

  公开号：

  KR20180007608A
• 作为产物：
  描述：

  在 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以100%的产率得到bis-MPA-OH dendrimer
  参考文献：
  名称：

  咪唑化物活化的化合物促进氟化物的酯化：树状聚合物的模块化和可持续方法

  摘要：

  基于对在结构上完美的聚合物的简便，可持续的合成方法不断增长的需求，我们在此描述了利用1,1'-羰基二咪唑（CDI）进行酯化反应的显着改进。氟化铯被证明是完成这些反应的必要催化剂。该方法已成功应用于采用传统和加速生长策略的结构无缺陷且功能强大的聚酯树枝状聚合物的合成。在不到一天的总反应时间内，分离出了分子量为22.080 Da和192个外围羟基的第六代bis-MPA树状聚合物。使用简单的纯化步骤，在可持续的条件下，可以高产率（> 90％）获得大量的树枝状大分子。

  DOI：

  10.1002/anie.201411370

文献信息

• Thiol-ene and thiol-yne-based synthesis of glycodendrimers as nanomolar inhibitors of wheat germ agglutinin
  作者：Mattia Ghirardello、Kim Öberg、Samuele Staderini、Olivier Renaudet、Nathalie Berthet、Pascal Dumy、Yvonne Hed、Alberto Marra、Michael Malkoch、Alessandro Dondoni

  DOI：10.1002/pola.27262

  日期：2014.9.1

  thiyl radicals, a collection of glycodendrimers with glycan density ranging from six to ninety‐six GlcNAc per dendrimer was obtained. The recognition properties of the prepared glycodendrimers toward the wheat germ agglutinin (WGA) were evaluated by enzyme‐linked lectin assay (ELLA). The eight glycodendrimers were excellent ligands showing IC50 values in the nanomolar range and relative potencies per

  制备了第1至第4代烯烃和炔烃功能性聚酯基树枝状聚合物，并在自由基条件下与2-乙酰氨基-2-脱氧-1-硫代-β - D-葡萄糖（GlcNAc-SH）反应。当烯烃-树状大分子每烯基添加一个硫基时，而每个炔基-树状大分子的yne基团都被两个噻吩基所饱和，因此获得了糖基树状大分子的集合，其聚糖密度为每个树状大分子六至九十六个GlcNAc。通过酶联凝集素测定法（ELLA）评估了制备的糖树状聚合物对小麦胚芽凝集素（WGA）的识别特性。八种糖树状聚合物是出色的配体，在纳摩尔范围内显示IC 50值，每糖单位的相对效能最高可达2.27 e 6与用作单价参考的单糖GlcNAc相比。©2014 Wiley Periodicals，Inc. J. Polym。科学，A部分：Polym。化学 2014，52，2422年至2433年
• Synthesis and characterization of ferrocenyl-functionalized polyester dendrimers and catalytic performance for thermal decomposition of ammonium perchlorate
  作者：Fengjuan Xiao、Xiaoai Sun、Xiangfeng Wu、Junchai Zhao、Yunjun Luo

  DOI：10.1016/j.jorganchem.2012.04.025

  日期：2012.8

  A novel ferrocene functionalized polyester dendrimer (PEDr-Fc) containing 6, 12 and 24 peripheral ferrocene moieties were obtained using the esterification reaction between ferrocene carboxylic and polyester dendrimer (PEDr). The H-1 NMR, C-13 NMR, MALDI-TOF mass spectra and elemental analysis techniques confirmed the structure of PEDr-Fc and provided evidences of the successful functionalization of PEDr by ferrocene with high yield over 92% and high grafting rate (more than 91%) of ferrocene on the terminals of dendrimer. The cyclic voltammogram measurements were carried out to analyze the redox properties of PEDr-Fcs. The catalytic performances for thermal decomposition of ammonium perchlorate (AP) were investigated by DSC techniques. The kinetic parameters were computed by the Kissinger method. PEDr-Fcs maintained the special redox properties by electron transfer of ferrocene/ferrocenium in ferrocene groups and all the redox centers were equivalent with no interaction between them. The electrode reactions of PEDr-Fcs were diffusion-controlled redox processes. PEDr-Fc presented an efficient catalytic effect on the thermal degradation of AP and the catalytic reactions were characterized by decreased activation energy and increased rate constant of thermal decomposition. The possible catalytic mechanism was that the electron transfer between Fe2+ and Fe3+ in ferrocene oxidized by AP and reduced by NH3 produced by the degradation of AP accelerated decomposition reaction below 300 degrees C, and the formation of iron clusters with large surface areas might cause the rupture of the chemical bond in AP at high temperature. (C) 2012 Elsevier B.V. All rights reserved.
• Near-infrared luminescent erbium complexes with 8-hydroxyquinoline-terminated hyperbranched polyester
  作者：Dan Liu、Chengjian Li、Yaling Xu、Dapeng Zhou、Hongmei Wang、Ping Sun、Huasheng Jiang

  DOI：10.1016/j.polymer.2017.02.061

  日期：2017.3

  Novel 8-hydroxyquinoline-terminated hyperbranched polyesters (1-HBPQ and 2-HBPQ) were synthesized and characterized by H-1-NMR and UV-Vis analyses. Then, two erbium complexes (1-HBPQ-Er3+-HQ and 2-HBPQ-Er3+-HQ) were prepared by using 1-HBPQ or 2-HBPQ as the macromolecular ligand and 8-hydroxyquinoline (HQ) as a second ligand. The FTIR spectra and UV-Vis absorption spectra confirmed that both the macromolecular ligand and the second ligand were successfully coordinated with Er3+ ions. The erbium complexes emitted intense near-infrared luminescence at about 1530 nm, which corresponds to the I-4(13/2)-I-4(15/2) transition of Er3+ ions. Moreover, their full width at half maximum (FWHM) values were greater than 80 nm. The erbium complexes exhibited good solubility in conventional solvents and excellent near-infrared luminescence properties, indicating their promising potential as gain medium materials in optical amplification devices. (C) 2017 Elsevier Ltd. All rights reserved.
• Hyperbranched Polyester Hydrogels with Controlled Drug Release and Cell Adhesion Properties
  作者：Hongbin Zhang、Alpesh Patel、Akhilesh K. Gaharwar、Silvia M. Mihaila、Giorgio Iviglia、Shilpaa Mukundan、Hojae Bae、Huai Yang、Ali Khademhosseini

  DOI：10.1021/bm301825q

  日期：2013.5.13

  Hyperbranched polyesters (HPE) have a high efficiency to encapsulate bioactive agents, including drugs, genes, and proteins, due to their globe-like nanostructure. However, the use of these highly branched polymeric systems for tissue engineering applications has not been broadly investigated. Here, we report synthesis and characterization of photocrosslinkable HPE hydrogels with sustained drug release characteristics for cellular therapies. These HPE can encapsulate hydrophobic drug molecules within the HPE cavities due to the presence of a hydrophobic inner structure that is otherwise difficult to achieve in conventional hydrogels. The functionalization of HPE with photocrosslinkable acrylate moieties renders the formation of hydrogels with a highly porous interconnected structure and mechanically tough network. The compressive modulus of HPE hydrogels was tunable by changing the crosslinking density. The feasibility of using these HPE networks for cellular therapies was investigated by evaluating cell adhesion, spreading, and proliferation on hydrogel surface. Highly crosslinked and mechanically stiff HPE hydrogels have higher cell adhesion, spreading, and proliferation compared to soft and complaint HPE hydrogels. Overall, we showed that hydrogels made from HPE could be used for biomedical applications that require spatial control of cell adhesion and controlled release of hydrophobic clues.
• HARD COATING COMPOSITION, AND HARD COATING FILM, WINDOW FILM AND DISPLAY DEVICE COMPRISING THE SAME
  申请人：Dongwoo Fine-Chem Co., Ltd.

  公开号：US20170313900A1

  公开（公告）日：2017-11-02

  Described is a hard coating composition composed of a silazane compound, a polyfunctional (meth)acryl-based dendrimer compound or a polyfunctional urethane (meth)acrylate having a cyclohexyl group, a photoinitiator and a solvent, and to a hard coating film, a window film, and a display device including the same, thus exhibiting superior scratch resistance, hardness and flexibility.