2,6-bis((4-((quinolin-8-yloxy)methyl)-1H-1,2,3-triazol-1-yl)methyl)pyridine | 1393549-47-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,6-bis((4-((quinolin-8-yloxy)methyl)-1H-1,2,3-triazol-1-yl)methyl)pyridine
• 英文别名: 8-[[1-[[6-[[4-(Quinolin-8-yloxymethyl)triazol-1-yl]methyl]pyridin-2-yl]methyl]triazol-4-yl]methoxy]quinoline
• CAS: 1393549-47-7
• 化学式: C₃₁H₂₅N₉O₂
• 分子量: 555.599
• InChiKey: VNJPAGHUARZDQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  42
• 可旋转键数：
  10
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  119
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  2,6-双(溴甲基)吡啶 在 copper(l) iodide 、 sodium azide 、 N,N-二异丙基乙胺 作用下， 以 二甲基亚砜 、 甲苯 、 叔丁醇 为溶剂， 反应 40.0h， 生成 2,6-bis((4-((quinolin-8-yloxy)methyl)-1H-1,2,3-triazol-1-yl)methyl)pyridine
  参考文献：
  名称：

  Reversible fluorescence sensing of Zn²⁺based on pyridine-constrainedbis(triazole-linked hydroxyquinoline) sensor

  摘要：

  Zinc ion (Zn2+) is an important and a most useful biological trace nutrient responsible for the activity of several enzymes. Zn2+ concentrations in the environment as well as in the human body increase beyond permissible limits as a consequence of its mining and widespread industrial applications. Such excess Zn2+ concentrations are toxic to humans and many aquatic organisms. The magnetic inertness and spin paired electronic configuration of Zn2+ makes it hard to detect by common analytical techniques. Therefore, fluorometric detection using chemosensor is the most effective tool for the environmental and biological detection of Zn2+. We have developed a novel pyridine-constrained bis(triazole-linked hydroxyquinoline) ligand as a reversible fluorescent chemosensor for Zn2+. The symmetrical ligand is highly selective for Zn2+ and fluoresces brightly upon complexation compared with other metal ions based on chelation-enhanced fluorescence mechanism. Interestingly, free ligand can be regenerated by treating the ligand-Zn2+ complex with aqueous ammonia.

  DOI：

  10.1080/10610278.2011.611245