6-amino-1,2-dihydroxyhexane | 89585-23-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-amino-1,2-dihydroxyhexane
• 英文别名: 6-Amino-1,2-Hexanediol；6-Aminohexane-1,2-diol
• CAS: 89585-23-9
• 化学式: C₆H₁₅NO₂
• mdl: MFCD19206489
• 分子量: 133.191
• InChiKey: ZJYJEANZJODQAE-UHFFFAOYSA-N

物化性质

• 熔点：
  76 °C
• 沸点：
  161-162 °C(Press: 5 Torr)
• 密度：
  1.051±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  [5-(氨基甲基)呋喃-2-基]甲醇 在 氢气 作用下， 以 环己烷 为溶剂， 75.0 ℃ 、6.0 MPa 条件下， 以60.7 %的产率得到6-amino-1,2-dihydroxyhexane
  参考文献：
  名称：

  一种氨基醇的制备方法

  摘要：

  本发明公开了一种氨基醇的制备方法。所述制备方法包括如下步骤：在负载型金属催化剂的催化作用下，糠胺、糠胺衍生物及它们的盐经氢解反应得到氨基醇类化合物。本发明首次实现了催化生物质基糠胺及其衍生物氢解制备氨基醇类化合物，反应条件温和，催化剂活性高，产物选择性高。本发明方法采用生物质基化合物作为原料，制备氨基醇类化合物，符合可持续发展和绿色化学的要求。本发明方法制得的氨基醇类化合物选择性高，便于产物的分离和提纯。本发明方法反应结束后，催化剂易于分离，且可回收重复利用，有很好的应用前景。

  公开号：

  CN116655476A

文献信息

• [EN] DUPLEX STABILIZING FLUORESCENCE QUENCHERS FOR NUCLEIC ACID PROBES<br/>[FR] EXTINCTEURS DE FLUORESCENCE STABILISANT LES DUPLEX POUR SONDES NUCLÉIQUES
  申请人：ELITECHGROUP INC

  公开号：WO2019036225A1

  公开（公告）日：2019-02-21

  Diaryl-azo derivatives are efficient fluorescence quenchers as well as nucleic acid duplex-stabilizing agents and are useful in oligonucleotide conjugates and probes. The oligonucleotide-quencher conjugates may be used in detection methods for nucleic acid targets.

  二苯基偶氮衍生物既是高效的荧光猝灭剂，又是核酸双链稳定剂，在寡核苷酸共轭物和探针中具有用途。寡核苷酸-猝灭剂共轭物可用于核酸靶标的检测方法中。
• [EN] DIASTEREOMERIC LINKING REAGENTS FOR NUCLEOTIDE PROBES<br/>[FR] RÉACTIFS DE LIAISON DIASTÉRÉOMÉRIQUES POUR SONDES NUCLÉOTIDIQUES
  申请人：BRENTANO BIOTECHNOLOGY ASS

  公开号：WO2021061154A1

  公开（公告）日：2021-04-01

  A versatile reagent with a non-nucleotide monomeric unit comprising an enantiomeric center and having a ligand, and first and second coupling groups that are linked to the non-nucleotide monomeric unit. Such a reagent permits preparation of versatile nucleotide/non-nucleotide polymers, having any desired sequence of nucleotide and non-nucleotide monomeric units, each of the latter of which bear a desired ligand. These polymers can, for example, be used as probes which can exhibit enhanced sensitivity and/or which are capable of detecting a genus of nucleotides each species of which has a common target nucleotide sequence of interest bridged by different sequences not of interest.

  一种多功能试剂，具有一个非核苷单体单元，包括一个对映中心和一个配体，以及与非核苷单体单元相连的第一和第二偶联基团。这种试剂可以制备多功能核苷酸/非核苷酸聚合物，具有任何所需的核苷酸和非核苷酸单体单元序列，其中每个后者都带有所需的配体。这些聚合物可以用作探针，可以展示增强的灵敏度和/或能够检测一类核苷酸，其中每个物种都有一个共同的感兴趣的靶核苷酸序列，通过不感兴趣的不同序列连接。
• HYBRIDIZATION AND MISMATCH DISCRIMINATION USING OLIGONUCLEOTIDES CONJUGATED TO MINOR GROOVE BINDERS
  申请人：HEDGPETH JOEL

  公开号：US20090048427A1

  公开（公告）日：2009-02-19

  Conjugates between a minor groove binding molecule, such as the trimer of 1,2-dihydro-(3H)-pyrrolo[3,2-e]indole-7-carboxylate (CDPI 3 ), and an oligonucleotide form unusually stable hybrids with complementary target sequences, in which the tethered CDPI 3 group resides in the minor groove of the duplex. These conjugates can be used as probes and primers. Due to their unusually high binding affinity, conjugates as short as 8-mers can be used as amplification primers with high specificity and efficiency. MGB conjugation also increases the discriminatory power of short oligonucleotides, providing enhanced detection of nucleotide sequence mismatches by short oligonucleotides. The MGB-conjugated probes and primers described herein facilitate various analytic and diagnostic procedures, such as amplification reactions, PCR, detection of single-nucleotide polymorphisms, gene hunting, differential display, fluorescence energy transfer, hydrolyzable probe assays and others; by allowing the use of shorter oligonucleotides, which have higher specificity and better discriminatory power.

  一种小沟结合分子（例如1,2-二氢-（3H）-吡咯并[3,2-e]吲哚-7-羧酸三聚体（CDPI3））与寡核苷酸之间的共轭体形成与互补靶序列异常稳定的杂交体，在其中，被拴在一起的CDPI3基团位于双链的小沟中。这些共轭体可用作探针和引物。由于它们的结合亲和力异常高，因此即使是长度为8个碱基的共轭体也可用作具有高特异性和效率的扩增引物。MGB共轭还增加了短寡核苷酸的鉴别能力，通过短寡核苷酸提供了更好的核苷酸序列不匹配检测。所述的MGB共轭探针和引物可促进各种分析和诊断过程，例如扩增反应，PCR，单核苷酸多态性检测，基因寻找，差异显示，荧光能量转移，可水解探针测定等；通过使用更短的寡核苷酸，从而具有更高的特异性和更好的鉴别能力。
• Non-nucleotide linking reagents for nucleotide probes
  申请人：GEN-PROBE INCORPORATED

  公开号：EP0313219A2

  公开（公告）日：1989-04-26

  A versatile reagent with a non-nucleotide monomeric unit having a ligand, and first and second coupling groups which are linked to the non-nucleotide monomeric unit. The ligand can be either a functional moiety, such as a label or intercalator, or a linking arm which can be linked to such a moiety. Such reagent permits preparation of versatile nucleotide/non-­nucleotide polymers, having any desired sequence of nucleotide and non-nucleotide monomeric units, each of the latter of which bear a desired ligand. These polymers can for example, be used as probes which can exhibit enhanced sensitivity and/or which are capable of detecting a genus of nucleotides each species of which has a common target nucleotide sequence of interest bridged by different sequences not of interest.

  一种多功能试剂，其非核苷酸单体单元具有配体以及与非核苷酸单体单元相连的第一和第二偶联基团。配体可以是功能性分子，如标记物或插入物，也可以是与功能性分子相连的连接臂。这种试剂可以制备多功能核苷酸/非核苷酸聚合物，具有任何所需的核苷酸和非核苷酸单体单元序列，其中每个单体单元都带有所需的配体。例如，这些聚合物可以用作探针，从而提高灵敏度和/或能够检测核苷酸属，其中每种核苷酸都有一个共同的目标核苷酸序列，并由不同的非目标核苷酸序列连接。
• Modified saccharides
  申请人：Novartis AG

  公开号：EP2548895A1

  公开（公告）日：2013-01-23

  Modified capsular saccharides comprising a blocking group at a hydroxyl group position on at least one of the monosaccharide units of the corresponding native capsular saccharide, wherein the blocking group is of the formula (Ia) or (Ib): -O-X-Y (Ia) or -O-R1 (Ib) wherein X is C(O), S(O) or SO2; Y is NR1R2 or R3; R1 is C1-6 alkyl substituted with 1, 2 or 3 groups independently selected from hydroxyl, sulphydryl and amine; R2 is H or C1-6 alkyl; and R3 is C1-6 alkyl; processes for modifying a capsular saccharide with the blocking groups; saccharide-protein conjugates comprising the modified capsular saccharide; processes for making the saccharide-protein conjugates, pharmaceutical compositions comprising the modified capsular saccharides and/or saccharide-protein conjugates; and methods and uses of the same.

  在相应的原生胶囊糖的至少一个单糖单元上的羟基位置上包含封端基团的改性胶囊糖，其中封端基团为式(Ia)或(Ib)：-其中X是C(O)、S(O)或SO2；Y是NR1R2或R3；R1是被1、2或3个独立选自羟基、亚砜基和胺的基团取代的C1-6烷基；R2是H或C1-6烷基；R3是C1-6烷基；用封端基团修饰胶囊糖的工艺；包含改性胶囊糖的糖-蛋白共轭物；糖-蛋白共轭物的制造工艺，包含改性胶囊糖和/或糖-蛋白共轭物的药物组合物；以及其方法和用途。