4-octyl-4,6-dihydro-3H-pyrano[3,2-c]quinoline-2,5-dione | 1448786-41-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-octyl-4,6-dihydro-3H-pyrano[3,2-c]quinoline-2,5-dione
• CAS: 1448786-41-1
• 化学式: C₂₀H₂₅NO₃
• 分子量: 327.423
• InChiKey: DTLTVGJAYZZJHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  丙二酸环(亚)异丙酯 、 壬醛 、 2,4-喹啉二醇 在 1-甲基-3-丁基咪唑硫酸氢盐 作用下， 反应 1.33h， 以74%的产率得到4-octyl-4,6-dihydro-3H-pyrano[3,2-c]quinoline-2,5-dione
  参考文献：
  名称：

  Synthesis of novel pyrano[3,2-c]quinoline-2,5-diones using an acidic ionic liquid catalyst

  摘要：

  The synthesis of novel 4-substituted-3,4-dihydro-6H-pyrano[3,2-c]quinoline-2,5-diones was accomplished efficiently via a three-component reaction between 4-hydroxyquinoline-2-one, Meldrum's acid, and an alkyl or arylaldehyde under catalysis by [Bmim]HSO4. The ionic liquid catalyst offers the advantage of realizing the synthesis of the title products at ambient temperature and widens the scope of the reactants to include aliphatic aldehydes with respect to the catalysts already applied for similar syntheses. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.06.050

文献信息

• Synthesis of novel pyrano[3,2-c]quinoline-2,5-diones using an acidic ionic liquid catalyst
  作者：Kurosh Rad-Moghadam、Seyyedeh Cobra Azimi、Esmayeel Abbaspour-Gilandeh

  DOI：10.1016/j.tetlet.2013.06.050

  日期：2013.8

  The synthesis of novel 4-substituted-3,4-dihydro-6H-pyrano[3,2-c]quinoline-2,5-diones was accomplished efficiently via a three-component reaction between 4-hydroxyquinoline-2-one, Meldrum's acid, and an alkyl or arylaldehyde under catalysis by [Bmim]HSO4. The ionic liquid catalyst offers the advantage of realizing the synthesis of the title products at ambient temperature and widens the scope of the reactants to include aliphatic aldehydes with respect to the catalysts already applied for similar syntheses. (C) 2013 Elsevier Ltd. All rights reserved.