4-(benzyloxy)octane-1,8-diol | 1466415-69-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-(benzyloxy)octane-1,8-diol
• 英文别名: 4-Phenylmethoxyoctane-1,8-diol；4-phenylmethoxyoctane-1,8-diol
• CAS: 1466415-69-9
• 化学式: C₁₅H₂₄O₃
• 分子量: 252.354
• InChiKey: UZENUIBFWBRTIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(benzyloxy)octane-1,8-diol 在 10 wt% Pd(OH)2 on carbon 、 氢气 作用下， 以 甲醇 为溶剂， 以97%的产率得到octane-1,4,8-triol
  参考文献：
  名称：

  Synthesis of Glycerol Homologues

  摘要：

  A series of monoprotected glycerol homologues and triols were prepared in high overall yields (>90%) via the hydroboration-oxidation of the corresponding dienols. Hydroboration with disiamylborane and concomitant alkaline oxidation (NaOH, H2O2) was found to be a mild, high-yielding, and highly efficient method for the construction of a variety of glycerol homologues.

  DOI：

  10.1055/s-0033-1339185
• 作为产物：
  描述：

  octa-1,7-dien-4-ol 在 二(3-甲基丁烷-2-基)硼烷 、 sodium hydride 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.25h， 生成 4-(benzyloxy)octane-1,8-diol
  参考文献：
  名称：

  Synthesis of Glycerol Homologues

  摘要：

  A series of monoprotected glycerol homologues and triols were prepared in high overall yields (>90%) via the hydroboration-oxidation of the corresponding dienols. Hydroboration with disiamylborane and concomitant alkaline oxidation (NaOH, H2O2) was found to be a mild, high-yielding, and highly efficient method for the construction of a variety of glycerol homologues.

  DOI：

  10.1055/s-0033-1339185

文献信息

• Synthesis of Glycerol Homologues
  作者：Mark Trudell、Kiran Thota

  DOI：10.1055/s-0033-1339185

  日期：——

  A series of monoprotected glycerol homologues and triols were prepared in high overall yields (>90%) via the hydroboration-oxidation of the corresponding dienols. Hydroboration with disiamylborane and concomitant alkaline oxidation (NaOH, H2O2) was found to be a mild, high-yielding, and highly efficient method for the construction of a variety of glycerol homologues.