ethyl 5-[N'-(chloro-ethoxycarbonyl-methylene)-hydrazine]-3-phenyl-1H-pyrazole-4-carboxylate | 1649479-42-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl 5-[N'-(chloro-ethoxycarbonyl-methylene)-hydrazine]-3-phenyl-1H-pyrazole-4-carboxylate
• CAS: 1649479-42-4
• 化学式: C₁₆H₁₇ClN₄O₄
• 分子量: 364.788
• InChiKey: JFTIEGHOOIUKRW-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  ethyl 5-[N'-(chloro-ethoxycarbonyl-methylene)-hydrazine]-3-phenyl-1H-pyrazole-4-carboxylate 在 三乙胺 作用下， 以 乙醇 为溶剂， 以60%的产率得到6-phenyl-1H-pyrazolo[5,1-c]-1,2,4-triazole-3,7-dicarboxylic acid diethyl ester
  参考文献：
  名称：

  Further Studies with Ethyl 5-Amino-3-phenyl-lH-pyrazole-4-carboxylate¹

  摘要：

  The newly synthesized ethyl 3‐amino‐5‐phenylpyrazole‐4‐carboxylate 1 was diazotized and coupled with β‐naphthol, active methylene reagents 6, 9, 12, 15, and the active methine 19 to afford the pyrazolo[5,1‐c]triazines 5, 8, 11, 14, 17, 18, and the pyrazolo[5,1‐c]‐1,2,4‐triazoles 21, 22, and 23, respectively. Structures are elucidated and mechanisms are discussed.

  DOI：

  10.1002/jhet.1802
• 作为产物：
  描述：

  2-氯乙酰乙酸乙酯 、 5-氨基-3-苯基-1H-吡唑-4-羧酸乙酯 在 盐酸 、 sodium nitrite 、 sodium acetate 作用下， 以 水 、 溶剂黄146 、 乙醇 为溶剂， 生成 ethyl 5-[N'-(chloro-ethoxycarbonyl-methylene)-hydrazine]-3-phenyl-1H-pyrazole-4-carboxylate
  参考文献：
  名称：

  Further Studies with Ethyl 5-Amino-3-phenyl-lH-pyrazole-4-carboxylate¹

  摘要：

  The newly synthesized ethyl 3‐amino‐5‐phenylpyrazole‐4‐carboxylate 1 was diazotized and coupled with β‐naphthol, active methylene reagents 6, 9, 12, 15, and the active methine 19 to afford the pyrazolo[5,1‐c]triazines 5, 8, 11, 14, 17, 18, and the pyrazolo[5,1‐c]‐1,2,4‐triazoles 21, 22, and 23, respectively. Structures are elucidated and mechanisms are discussed.

  DOI：

  10.1002/jhet.1802