1,2;5,6-di-O-isopropylidene-α-D-glucofuranos-3-yl tetramethylphosphorodiamidite | 64786-60-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,2;5,6-di-O-isopropylidene-α-D-glucofuranos-3-yl tetramethylphosphorodiamidite
• CAS: 64786-60-3
• 化学式: C₁₆H₃₁N₂O₆P
• 分子量: 378.406
• InChiKey: AHLDJKRTHLKRCV-RKQHYHRCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.75
• 重原子数：
  25.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  61.86
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  双丙酮葡萄糖 、 三(二甲胺基)膦 反应 5.0h， 以80%的产率得到1,2;5,6-di-O-isopropylidene-α-D-glucofuranos-3-yl tetramethylphosphorodiamidite
  参考文献：
  名称：

  Complexes of Copper, Silver, and Molybdenum with Glucofuranose Phosphoramidites

  摘要：

  Complex formation of 1,2;5,6-di-O-isopropylidene-alpha-D-glucofuranos-3-yl phosphorodiamidite and bis(1,2;5,6-di-O-isopropylidene-alpha-D--lucofuranos-3-yl) phosphoramidite with copper(I) and silver bromides and molybdenum hexacarbonyl is carried out.

  DOI：

  10.1023/b:rugc.0000015980.82586.08

文献信息

• New type phosphorous amides derived from protected monosaccharides
  作者：D. V. Khodarev、T. S. Kukhareva、L. K. Vasyanina、E. E. Nifant’ev

  DOI：10.1134/s1070363206040062

  日期：2006.4

  Three synthetic routes to hydrogen phosphoramidites derived from protected hydrocarbons containing one free secondary hydroxy group are explored: phosphorylation with (diethylamido)phosphorous dichloride, acidolysis of tetraalkyldiamides derived from sugars, and phosphorylation with phosphorous tetra-alkyldiamides. The last route was found to be preferred. Some properties of the prepared dialkylamidoglycophosphites were studied: stability, phosphorylating activity, and behavior in oxidation reactions.