ethyl 3-(2,5-dimethyl-1H-pyrrol-3-yl)cinnamate | 628314-44-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: ethyl 3-(2,5-dimethyl-1H-pyrrol-3-yl)cinnamate
• 英文别名: ethyl (Z)-3-(2,5-dimethyl-1H-pyrrol-3-yl)-3-phenylprop-2-enoate
• CAS: 628314-44-3
• 化学式: C₁₇H₁₉NO₂
• 分子量: 269.343
• InChiKey: IZZQRVGUJVMBNW-WJDWOHSUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  42.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,5-二甲基吡咯 、 苯丙炔酸乙酯 在 potassium tetrachloroplatinate 、 silver trifluoromethanesulfonate 作用下， 以 溶剂黄146 为溶剂， 反应 24.0h， 生成 ethyl 3-(2,5-dimethyl-1H-pyrrol-3-yl)cinnamate 、 ethyl 3-(2,5-dimethyl-1H-pyrrol-3-yl)cinnamate
  参考文献：
  名称：

  Pt(II)-catalyzed hydroarylation reaction of alkynes with pyrroles and furans

  摘要：

  A Pt(II) catalyst showed a drastic effect on hydroarylation of alkynes with pyrroles and furans compared with Pd(OAc)(2) catalyst. The hydroarylation reactions proceeded smoothly under mild conditions to double-hydroarylation products in good yields. Mono-adducts Were formed only when the second hydroarylation was inhibited by steric hindrance Of Substrates or low reactivity of the mono-adducts. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.03.022

文献信息

• Pt(II)-catalyzed hydroarylation reaction of alkynes with pyrroles and furans
  作者：Juzo Oyamada、Tsugio Kitamura

  DOI：10.1016/j.tet.2009.03.022

  日期：2009.5

  A Pt(II) catalyst showed a drastic effect on hydroarylation of alkynes with pyrroles and furans compared with Pd(OAc)(2) catalyst. The hydroarylation reactions proceeded smoothly under mild conditions to double-hydroarylation products in good yields. Mono-adducts Were formed only when the second hydroarylation was inhibited by steric hindrance Of Substrates or low reactivity of the mono-adducts. (C) 2009 Elsevier Ltd. All rights reserved.