3-[1,3]-dioxan-2-ylmethyl-2-hydroxybenzaldehyde | 1027382-06-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-[1,3]-dioxan-2-ylmethyl-2-hydroxybenzaldehyde
• 英文别名: 3-[1,3]-Dioxan-2-ylmethyl-2-hydroxybenzaldehyde；3-(1,3-dioxan-2-ylmethyl)-2-hydroxybenzaldehyde
• CAS: 1027382-06-4
• 化学式: C₁₂H₁₄O₄
• 分子量: 222.241
• InChiKey: GWXYQAWRQKHVCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-{2-(Tert-butyldimethylsilanyloxy)ethyl]-3-[1-(tert-butyldimethylsilanyloxy)-2,2,2-trichloroethyl]benzyl}-[1,2]dioxane 在 四丁基氟化铵 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以93%的产率得到3-[1,3]-dioxan-2-ylmethyl-2-hydroxybenzaldehyde
  参考文献：
  名称：

  tert-Butyldimethylsilyloxytrichloromethylmethane—readily accessible and robust protecting group for (hetero)aryl aldehydes

  摘要：

  The tert-butyldimethylsilyloxytrichloromethylmethane (TBSTCM) substituent serves as a readily accessible masking group for aromatic and heteroaromatic aldehydes. The TBSTCM substituent is compatible with a range of common reagents and offers several strategic advantages over alternative aldehyde protecting groups. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.02.072

文献信息

• tert-Butyldimethylsilyloxytrichloromethylmethane—readily accessible and robust protecting group for (hetero)aryl aldehydes
  作者：Lauren R. Cafiero、Timothy S. Snowden

  DOI：10.1016/j.tetlet.2008.02.072

  日期：2008.4

  The tert-butyldimethylsilyloxytrichloromethylmethane (TBSTCM) substituent serves as a readily accessible masking group for aromatic and heteroaromatic aldehydes. The TBSTCM substituent is compatible with a range of common reagents and offers several strategic advantages over alternative aldehyde protecting groups. (C) 2008 Elsevier Ltd. All rights reserved.