2-oxo-quinoline-3-carbaldehyde-3,4-dimethylpyrryl-2-carboxylic acid hydrazone | 1257310-24-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-oxo-quinoline-3-carbaldehyde-3,4-dimethylpyrryl-2-carboxylic acid hydrazone
• CAS: 1257310-24-9
• 化学式: C₁₇H₁₆N₄O₂
• 分子量: 308.34
• InChiKey: LVYATQPVIQSTAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.24
• 重原子数：
  23.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  90.11
• 氢给体数：
  3.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  3,4-dimethylpyrrolyl-2-carboxylic acid hydrazide 、 1,2-二氢-2-氧代喹啉-3-甲醛 以 乙醇 为溶剂， 反应 12.0h， 以80%的产率得到2-oxo-quinoline-3-carbaldehyde-3,4-dimethylpyrryl-2-carboxylic acid hydrazone
  参考文献：
  名称：

  Crystal structures, DNA-binding and cytotoxic activities studies of Cu(II) complexes with 2-oxo-quinoline-3-carbaldehyde Schiff-bases

  摘要：

  Three novel 2-oxo-quinoline-3-carbaldehyde Schiff-bases and their Cu(II) complexes were synthesized. The molecular structures of Cu(II) complexes were determined by X-ray crystal diffraction. The DNA-binding modes of the complexes were also investigated by UV vis absorption spectrum, fluorescence spectrum, viscosity measurement and EB-DNA displacement experiment. The experimental evidences indicated that the ligands and Cu(II) complexes could interact with CT-DNA (calf-thymus DNA) through intercalation, respectively. Comparative cytotoxic activities of ligands and Cu(II) complexes were also determined by MTT [3-(4,5-dimethyl-2-thiazoyl)-2,5-diphenyl-2H-tetrazolium bromide] and SRB (sulforhodamine B) methods. The results showed that the three Cu(II) complexes exhibited more effective cytotoxic activity against HL60 cells and HeLa cells than corresponding ligands. Also, CuL3 showed higher cytotoxic activity than CuL1 and CuL2 (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.08.060