(2R,3S,4S,5R,6R)-5-Acetoxy-6-((2R,3R,4S,5R)-6-acetoxy-2-acetoxymethyl-5-benzyloxy-4-methoxy-tetrahydro-pyran-3-yloxy)-3,4-dimethoxy-tetrahydro-pyran-2-carboxylic acid benzyl ester | 209802-87-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3S,4S,5R,6R)-5-Acetoxy-6-((2R,3R,4S,5R)-6-acetoxy-2-acetoxymethyl-5-benzyloxy-4-methoxy-tetrahydro-pyran-3-yloxy)-3,4-dimethoxy-tetrahydro-pyran-2-carboxylic acid benzyl ester
• CAS: 209802-87-9
• 化学式: C₃₅H₄₄O₁₅
• 分子量: 704.725
• InChiKey: BGRXDURIKMVULO-GFBAQIKPSA-N

物化性质

• 沸点：
  726.018±60.00 °C(Press: 760.00 Torr)(predicted)
• 密度：
  1.295±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  (2R,3S,4S,5R,6R)-5-Acetoxy-6-((2R,3R,4S,5R)-6-acetoxy-2-acetoxymethyl-5-benzyloxy-4-methoxy-tetrahydro-pyran-3-yloxy)-3,4-dimethoxy-tetrahydro-pyran-2-carboxylic acid benzyl ester 在 哌啶 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 以84%的产率得到(2R,3S,4S,5R,6R)-5-Acetoxy-6-((2R,3R,4S,5R)-2-acetoxymethyl-5-benzyloxy-6-hydroxy-4-methoxy-tetrahydro-pyran-3-yloxy)-3,4-dimethoxy-tetrahydro-pyran-2-carboxylic acid benzyl ester
  参考文献：
  名称：

  In vitro evaluation of synthetic heparin-like conjugates comprising different thrombin binding domains

  摘要：

  The syntheses of several heparin-like glycoconjugates (i.e., 16a-f) containing identical AT III binding domains (ABD) and spacers but different thrombin binding domains (TBDs) are described.(1) Biological activities of conjugates 16a-f indicate that the thrombin inhibitory activity is mainly determined by the charge density of the TBD moiety. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00196-6
• 作为产物：
  描述：

  乙酸酐 、 (2R,3S,4S,5R,6R)-5-Acetoxy-6-((2R,3R,4S,5R,6S)-5-benzyloxy-2-benzyloxymethyl-4,6-dimethoxy-tetrahydro-pyran-3-yloxy)-3,4-dimethoxy-tetrahydro-pyran-2-carboxylic acid benzyl ester 在 硫酸 作用下， 反应 0.25h， 生成 (2R,3S,4S,5R,6R)-5-Acetoxy-6-((2R,3R,4S,5R)-6-acetoxy-2-acetoxymethyl-5-benzyloxy-4-methoxy-tetrahydro-pyran-3-yloxy)-3,4-dimethoxy-tetrahydro-pyran-2-carboxylic acid benzyl ester
  参考文献：
  名称：

  In vitro evaluation of synthetic heparin-like conjugates comprising different thrombin binding domains

  摘要：

  The syntheses of several heparin-like glycoconjugates (i.e., 16a-f) containing identical AT III binding domains (ABD) and spacers but different thrombin binding domains (TBDs) are described.(1) Biological activities of conjugates 16a-f indicate that the thrombin inhibitory activity is mainly determined by the charge density of the TBD moiety. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00196-6